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119020-01-8 Usage


(S)-1-N-Boc-2-(aminomethyl)pyrrolidine, also known as (S)-2-Aminomethyl-1-Boc-pyrrolidine, is a chiral and heterocyclic compound with a solid state. It is characterized by its unique molecular structure, which features a pyrrolidine ring with a protected amine group and an additional aminomethyl group. (S)-1-N-Boc-2-(aminomethyl)pyrrolidine is significant in the field of organic synthesis and synthetic chemistry due to its versatile reactivity and potential applications.


Used in Organic Synthesis:
(S)-1-N-Boc-2-(aminomethyl)pyrrolidine is used as an intermediate in organic synthesis for the development of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for the creation of complex molecules with specific stereochemistry, which is crucial for the biological activity and selectivity of the final products.
Used in Synthetic Chemistry:
In synthetic chemistry, (S)-1-N-Boc-2-(aminomethyl)pyrrolidine serves as a chiral and heterocyclic building block. Its incorporation into larger molecules can provide novel properties and functionalities, making it a valuable component in the design and synthesis of advanced materials, catalysts, and other specialty chemicals.
Used in Pharmaceutical Industry:
(S)-1-N-Boc-2-(aminomethyl)pyrrolidine is used as a key component in the synthesis of various pharmaceuticals, particularly those with chiral centers. Its presence in the final drug molecule can significantly influence the drug's efficacy, safety, and pharmacokinetic properties, making it an essential part of the drug development process.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-1-N-Boc-2-(aminomethyl)pyrrolidine is employed in the development of chiral pesticides, herbicides, and other crop protection agents. Its incorporation into these molecules can enhance their selectivity and reduce the environmental impact, leading to more sustainable and effective agricultural practices.
Used in Specialty Chemicals:
(S)-1-N-Boc-2-(aminomethyl)pyrrolidine is also utilized in the production of specialty chemicals, such as chiral ligands, catalysts, and other high-value compounds. Its unique properties and reactivity make it an attractive building block for the development of innovative products with specific applications in various industries, including materials science, electronics, and biotechnology.

Check Digit Verification of cas no

The CAS Registry Mumber 119020-01-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,0,2 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 119020-01:
78 % 10 = 8
So 119020-01-8 is a valid CAS Registry Number.

119020-01-8 Well-known Company Product Price

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  • TCI America

  • (A2473)  (S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine  >98.0%(GC)(T)

  • 119020-01-8

  • 1g

  • 695.00CNY

  • Detail
  • Alfa Aesar

  • (H52727)  (S)-2-Aminomethyl-1-Boc-pyrrolidine, 97%   

  • 119020-01-8

  • 1g

  • 698.0CNY

  • Detail
  • Alfa Aesar

  • (H52727)  (S)-2-Aminomethyl-1-Boc-pyrrolidine, 97%   

  • 119020-01-8

  • 5g

  • 2788.0CNY

  • Detail
  • Aldrich

  • (672084)  (S)-2-(Aminomethyl)-1-Boc-pyrrolidine  97%

  • 119020-01-8

  • 672084-100MG

  • 489.06CNY

  • Detail
  • Aldrich

  • (672084)  (S)-2-(Aminomethyl)-1-Boc-pyrrolidine  97%

  • 119020-01-8

  • 672084-500MG

  • 3,266.64CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name (S)-2-(Aminomethyl)-1-Boc-pyrrolidine

1.2 Other means of identification

Product number -
Other names (S)-tert-Butyl 2-(aminomethyl)pyrrolidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119020-01-8 SDS

119020-01-8Relevant articles and documents

Condensation approach to aliphatic oligourea foldamers: Helices with N-(Pyrrolidin-2-ylmethyl)ureido junctions

Fremaux, Juliette,Fischer, Lucile,Arbogast, Thomas,Kauffmann, Brice,Guichard, Gilles

, p. 11382 - 11385 (2011)

Caught in a fold: A simple and efficient coupling strategy to make aliphatic oligourea foldamers is reported. Crystal structures show that the pyrrolidine units (red; see picture) do not impair the 2.5-helical folding of the oligoureas. This modular strategy enables assembly of long helical segments containing non-adjacent pyrrolidine units as exemplified by the synthesis of a helix that is approximately 40 long.

Synthesis and in vivo evaluation of 11C-labeled (1,7-dicarba-closo-dodecaboran-1-yl)-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl} amide

G?mez-Vallejo, Vanessa,Vázquez, Naiara,Gona, Kiran Babu,Puigivila, Maria,González, Mikel,Sebastián, Eneko San,Martin, Abraham,Llop, Jordi

, p. 209 - 214 (2014)

Boron clusters, and especially dicarba-closo-dodecaboranes, can be used as hydrophobic pharmacophores in the design of new drugs and radiotracers because of their hydrophobic character, spherical structure, and excellent chemical and photochemical stability. In the present paper, the synthesis and in vivo evaluation of 11C-labeled (1,7-dicarba-closo-dodecaboran-1-yl)-N- {[(2S)-1-ethylpyrrolidin-2-yl]methyl}amide, an analog of the D2 receptor ligand [11C]raclopride, is described. The radiosynthesis was approached by reaction of the demethylated precursor with [11C] CH3I in basic media; moderate radiochemical yields (18.2 ± 2.8%, decay corrected), and excellent radiochemical purities (>98%) were obtained in overall synthesis time of ~50 min. In vivo assays showed a biodistribution pattern with significant uptake in liver, kidneys and lungs at short times (t = 4 min) after administration and increasing accumulation in bladder at longer times (t ≥ 14.5 min). Although brain positron emission tomography scans showed good blood brain barrier penetration, the high unspecific uptake observed in different brain regions impedes its applicability as D2 receptor ligand.

Application of Proline-Derived (Thio)squaramide Organocatalysts in Asymmetric Diels-Alder and Conjugate Addition Reactions

Bagi, Péter,Dargó, Gyula,Drahos, László,Huszthy, Péter,Kis, Dávid,Kupai, József,Mátrav?lgyi, Béla,Nagy, Sándor,Tóth, Blanka

, (2022/02/22)

The synthesis of chiral proline-derived squaramide and thiosquaramide organocatalysts, which are capable of the dual activation in asymmetric reactions is reported. The (thio)squaramide moiety can form hydrogen bonds to activate the substrates and to stereocontrol the reaction, while the pyrrolidine unit can form enamines to activate carbonyl compounds via aminocatalysis. Comparing the performance of thiosquaramide to squaramide, the Diels Alder reaction of (anthracen-9-yl)acetaldehyde and trans-?-nitrostyrene was examined, which has been investigated in the literature using quantum chemical calculations. Both squaramide and thiosquaramide gave excellent yields (up to 99%) and enantiomeric excess values (up to 98%). Moreover, their catalytic performance was compared in conjugate addition of lawsone to ?,?-unsaturated ?-keto ester.



Paragraph 0112; 0114, (2019/03/14)

The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in fomulas (I) or a pharmaceutically acceptable salt thereof.

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