1186435-64-2Relevant academic research and scientific papers
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1
Greiner, Christine,Zettl, Heiko,Koeberle, Andreas,Pergola, Carlo,Northoff, Hinnak,Schubert-Zsilavecz, Manfred,Werz, Oliver
, p. 3394 - 3401 (2011/07/08)
5-Lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase (mPGES)-1 are key enzymes in the biosynthesis of leukotrienes and prostaglandin (PG)E2, respectively, and are considered as valuable targets for the treatment of inflamma
Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARα agonists
Zettl, Heiko,Steri, Ramona,Laemmerhofer, Michael,Schubert-Zsilavecz, Manfred
supporting information; experimental part, p. 4421 - 4426 (2010/04/05)
A novel and robust scaffold for highly active PPARα agonists based on the 2-mercaptohexanoic acid substructure is presented. Systematic structural variation of the substitution pattern of the phenolic backbone yielded detailed SAR especially of ortho and
