118653-35-3

Upstream product

• 84353-56-0 (E)-N-(2-phenylethenyl)-2,2,2-trifluoroacetamide 
• 4306-25-6 (S)-2-phthalimidopropionyl chloride 
• 1722-84-5 (E)-N-styrylacetamide 
• 33066-20-5 (E)-1-isocyanato-2-phenylethene 
• 118653-26-2 [(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-((E)-styryl)-carbamic acid methyl ester 
• 118653-04-6 cis-N-methoxycarbonyl-2-phenylethenylamine 
• 60995-82-6 ((Z)-2-Isocyanato-vinyl)-benzene 
• 118653-26-2 [(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propionyl]-((Z)-styryl)-carbamic acid methyl ester 
• 118653-24-0 methyl(E)-N-formyl-N-(2-phenylethenyl)acetamide 
• 73885-72-0 trans-N-methoxycarbonyl-2-phenylethenylamine 

Relevant academic research and scientific papers

Synthesis of Enamides

(Z)-3-Arylprop-2-enoic acids can be converted by the Curtius procedure, through the acyl azides, into (Z)-2-arylethenyl isocyanates, which with methanol give methyl (Z)-N-(2-arylethenyl)carbamates.Acylation of the (Z)-enecarbamates, through their anions, leads to methyl (Z)-N-acyl-N-(2-arylethenyl)carbamates, which on treatment with lithium iodide in boiling N,N-dimethylformamide or acetonitrile undergo demethoxycarbonylation to give (Z)-enamides.The stereospecific route to enamides can also be used in the E-series.Treatment of (Z)- or (E)-2-arylethenyl isocyanates with trifluoroacetic acid gives (E)-N-(2-arylethenyl)trifluoroacetamides,the anions of which, with acylating agents, give (E)-enamides directly.