1186612-87-2

Upstream product

• 551-93-9 2-aminoacetophenone 

Downstream Products

• 1357098-92-0 ethyl 2-(4-[(E)-3-(2,4-dimethyl-3-quinolyl)-3-oxo-1-propenyl]-2-methoxyphenoxy)acetate 
• 1357098-95-3 4β-[6-(4-[(E)-3-(2,4-dimethyl-3-quinolyl)-3-oxo-1-propenyl]-2-methoxyphenoxy)hexanamido]-4-deoxypodophyllotoxin 
• 1357098-94-2 4β-[2-(4-[(E)-3-(2,4-dimethyl-3-quinolyl)-3-oxo-1-propenyl]-2-methoxyphenoxy)acetamido]-4-deoxypodophyllotoxin 
• 1357098-93-1 2-(4-[(E)-3-(2,4-dimethyl-3-quinolyl)-3-oxo-1-propenyl]-2-methoxyphenoxy)acetic acid 

Relevant academic research and scientific papers

Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents

A series of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxin congeners have been synthesized. All the twenty nine compounds were evaluated for anticancer activity against five human cancer cell lines (A-549, A375, MCF-7, HT-29 and ACHN). Some of the synthesized compounds showed good anticancer activity that is comparable to etoposide. The IC50 of compounds 17a and 17f is 2.7 and 2.1 μM respectively against A-549 cancer cell line. Flow cytometric analysis showed that these two compounds arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggested that 17a and 17f induced cell death by apoptosis.