118664-19-0Relevant academic research and scientific papers
High pressure activation in the asymmetric Michael addition of chiral imines to alkyl and aryl crotonates
Camara, Cheikhou,Joseph, Delphine,Dumas, Fran?oise,D'Angelo, Jean,Chiaroni, Angèle
, p. 1445 - 1448 (2007/10/03)
High pressure-mediated Michael addition of chiral imines derived from 2-methylcyclopentanone, 2-methylcyclohexanone and optically active 1-phenylethylamine, to methyl and phenyl crotonates was investigated. The corresponding adducts were obtained in fair yields and with a high degree of regio-, diastereo- and enantioselectivity.
THE ASYMMETRIC MICHAEL ADDITION PROCESS INVOLVING CHIRAL IMINES : STEREOCHEMICAL DATA IN SUPPORT OF A CYCLIC-LIKE TRANSITION STATE
d' Angelo, Jean,Guingant, Andre,Riche, Claude,Chiaroni, Angele
, p. 2667 - 2670 (2007/10/02)
Addition of imine 4 to Michael acceptors 5 and 8 are both highly selective processes.The observed stereocontrol of the newly created asymmetric centers in the resulting adducts strongly supports cyclic-like transition states.
