352695-16-0

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 583-60-8 2-Methylcyclohexanone 

Downstream Products

• 104823-09-8 1-{(S)-1-Methyl-2-[(E)-(R)-1-phenyl-ethylimino]-cyclohexyl}-pentan-3-one 
• 144462-21-5 2-(2,2-Bis-benzenesulfonyl-ethyl)-2-methyl-cyclohexanone 
• 144462-22-6 (2S,6R)-2-(2,2-Bis-benzenesulfonyl-ethyl)-6-methyl-cyclohexanone 
• 144462-22-6 (2S,6S)-2-(2,2-Bis-benzenesulfonyl-ethyl)-6-methyl-cyclohexanone 
• 53068-89-6 (R)-(+)-2-(2'-carbomethoxyethyl)-2-methylcyclohexanone 
• 161151-77-5 *,S^*)>-α-(acetyloxy)-1-methyl-2-oxocyclohexanepropanoic acid methyl ester 
• 207506-24-9 (R)-2-[(5S,7R)-8-Azido-7-(tert-butyl-dimethyl-silanyloxy)-5-methyl-3-oxo-octyl]-2-methyl-cyclohexanone 
• 441350-32-9 (S)-3-{(S)-1-Methyl-2-[(E)-(R)-1-phenyl-ethylimino]-cyclohexyl}-butyric acid methyl ester 
• 118664-19-0 (4R,4aS)-4,4a-Dimethyl-1-((R)-1-phenyl-ethyl)-3,4,4a,5,6,7-hexahydro-1H-quinolin-2-one 
• 787610-05-3 2-(Diethoxy-phosphoryl)-3-((S)-1-methyl-2-oxo-cyclohexyl)-propionic acid 
• 63975-59-7 (R)-(-)-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalene-2-one 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 91306-30-8 (R)-(+)-2-methyl-2-(3-oxobutyl)cyclohexanone 
• 125446-66-4 (S)-2-methyl-2-(3-oxopentyl)cyclohexanone 

Relevant academic research and scientific papers

TETRAHYDRONAPHTHALENE DERIVATIVES USEFUL AS NRF2 ACTIVATORS

Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.

INDOLE CARBOXAMIDE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein.

Diastereo- and enantioselective synthesis of bicyclic α-methylene- δ-valerolactones by asymmetric Michael reaction

A synthesis of optically active α-methylene-δ-valerolactones 7 and 13 with 97% ee was achieved by employing a highly stereoselective Michael reaction between chiral imines 2, 9 and the acrylate 3. Reduction of the carbonyl group of the resulting adducts 4

High pressure activation in the asymmetric Michael addition of chiral imines to alkyl and aryl crotonates

High pressure-mediated Michael addition of chiral imines derived from 2-methylcyclopentanone, 2-methylcyclohexanone and optically active 1-phenylethylamine, to methyl and phenyl crotonates was investigated. The corresponding adducts were obtained in fair yields and with a high degree of regio-, diastereo- and enantioselectivity.

Enantioselective syntheses of (2S,4AS,8aR)-1,1-4a-trimethyldecahydronaphthalen-2-ol[(-)-TMD], (4aS,8aR)-5,58a-trimethyloctahydronaphthalen-2(1H)-one, and (-)-Polywood, through Michael-type reaction of chiral imines

The title compounds 6, 15, and 17 have been synthesized in a straightforward way in good yields and high enantiomeric excesses by the chiral imines method, leading to building-blocks 2 and 10, followed by a few conventional steps.

ASYMMETRIC MICHAEL-TYPE ALKYLATION OF CHIRAL IMINES. ENANTIOSELECTIVE SYNTHESES OF (-)-GEOSMIN AND TWO OTHER RELATED NATURAL TERPENES, AS WELL AS ENANT-(+)-GEOSMIN

Natural (-)-geosmin 11, (+)-octalone 14 (from Vetiveria zizanioides), and (+)-octalin 15 (from Bazzania fauriana and B. angustifolia) have been prepared in high chemical and enantiomeric yields via the asymmetric process involving Michael-type alkylation of chiral imines 6 and 12.Enant-(+)-geosmin has been also synthesized by the same procedure.