1186642-19-2Relevant academic research and scientific papers
Rhodium(III)-catalyzed ortho alkenylation of n-phenoxyacetamides with n-tosylhydrazones or diazoesters through C-H activation
Hu, Fangdong,Xia, Ying,Ye, Fei,Liu, Zhenxing,Ma, Chen,Zhang, Yan,Wang, Jianbo
, p. 1364 - 1367 (2014/03/21)
A coupling reaction of N-phenoxyacetamides with N-tosylhydrazones or diazoesters through RhIII-catalyzed C-H activation is reported. In this reaction, ortho-alkenyl phenols were obtained in good yields and with excellent regio- and stereoselectivity. Rh-c
Highly enantioselective hydrogenation of styrenes directed by 2′-hydroxyl groups
Wang, Xiang,Guram, Anil,Caille, Seb,Hu, Jack,Preston,Ronk, Michael,Walker, Shawn
, p. 1881 - 1883 (2011/05/15)
A new synthetic strategy that turns styrene-type olefins into excellent substrates for Rh-catalyzed asymmetric hydrogenation by installing a 2′-hydroxyl substituent is described. This methodology accommodates trisubstituted olefinic substrates in various E/Z mixtures, leading to valuable benzylic chiral compounds including (R)-tolterodine. It is also demonstrated that the 2′-hydroxyl groups could be readily removed in high yield without loss of ee from the products. Thus, this technology represents an attractive alternative to the Ir(P-N) catalyst system for the asymmetric hydrogenation of unfunctionalized olefins.
Palladium catalyzed isomerization of alkenes: A pronounced influence of an o-phenol hydroxyl group
Fan, Jinmin,Wan, Changfeng,Wang, Qiang,Gao, Linfeng,Zheng, Xiaoqi,Wang, Zhiyong
supporting information; experimental part, p. 3168 - 3172 (2011/02/25)
A novel palladium catalyzed isomerization of alkenes has been found, where an ortho-phenol hydroxyl group has a pronounced influence on the isomerization.
