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1186645-15-7

1186645-15-7

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1186645-15-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1186645-15-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,6,6,4 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1186645-15:
(9*1)+(8*1)+(7*8)+(6*6)+(5*6)+(4*4)+(3*5)+(2*1)+(1*5)=177
177 % 10 = 7
So 1186645-15-7 is a valid CAS Registry Number.

1186645-15-7Downstream Products

1186645-15-7Relevant articles and documents

Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists

Bakir, Farid,Kher, Sunil,Pannala, Madhavi,Wilson, Norma,Nguyen, Trang,Sircar, Ila,Takedomi, Kei,Fukushima, Chiaki,Zapf, James,Xu, Kui,Zhang, Shao-Hui,Liu, Juping,Morera, Lisa,Schneider, Lisa,Sakurai, Naoki,Jack, Rick,Cheng, Jie-Fei

, p. 3473 - 3479 (2008/09/19)

A structurally novel liver X receptor (LXR) agonist (1) was identified from internal compound collection utilizing the combination of structure-based virtual screening and high-throughput gene profiling. Compound 1 increased ABCA1 gene expression by eightfold and SREBP1c by threefold in differentiated THP-1 macrophage cell lines. Confirmation of its agonistic activity against LXR was obtained in the co-factor recruitment and reporter transactivation assays. Structure-activity relationship studies on compound 1 are described.

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