118671-32-2

Upstream product

• 118671-18-4 methyl 4,5-dimethoxy-2-N-benzeneacetate 
• 4697-57-8 methyl 2-(2-bromo-4,5-dimethoxyphenyl)acetate 
• 118671-08-2 N-Benzyl-N-(2-cyanomethyl-4,5-dimethoxy-phenyl)-acetamide 
• 118671-04-8 4,5-dimethoxy-2-<(phenylmethyl)amino>benzeneacetonitrile 
• 100-52-7 benzaldehyde 
• 50546-80-0 (2-amino-4,5-dimethoxy-phenyl)-acetonitrile 

Relevant academic research and scientific papers

A practical synthesis of indoles via a Pd-catalyzed C-N ring formation

A method for the synthesis of N-functionalized C2-/C3-substituted indoles via Pd-catalyzed C-N bond coupling of halo-aryl enamines is described. The general strategy utilizes a variety of amines and β-keto esters which are elaborated into halo-aryl enamin

Synihesis of 3-substituied indoles via a modified madeling reaction

Anilides 4a-c,e-k, lla-d in which the amide function is benzylated, or silylated and having different electron-withdrawing groups (EWG) at the methyl methyl in the ortho position of the amide function, cyclize under the influence of potassium tert-butoxide to the corresponding indole derivatives 5a-c,e-k and 9a-d, respectively, under these conditions the chloroacetamides 4d,n and 11e are converted into the tetrahydroquinolines 6a,b and 12, respectively. Treatment of chloroacetamide 4m with KOt-Bu gave, in addition to starting material, indole 5m, tetrahydroquinoline 6c and 2(1H)-quinolinone 7. When 3-indolecarbonitrile 5a is treated with sodium in liquid amnonia debenzylation takes place, while after catalytic hydrogenation with 5% Pd/C the corresponding 2,3-dirnethylindole 8 is formed.