1187-34-4

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL N-(2-CYANO-3-ETHOXYACRYLOYL)CARBAMATE is used as an active ingredient for the development of pharmaceutical drugs. Its carbamate ester structure and functional groups contribute to its potential therapeutic applications, although more research may be needed to fully understand its effects and safety profile.
Used in Pesticide Industry:
ETHYL N-(2-CYANO-3-ETHOXYACRYLOYL)CARBAMATE is used as an active ingredient in pesticides. Its chemical structure allows it to target pests effectively, providing a means of pest control in agricultural settings. However, as with any pesticide, it is crucial to follow safety guidelines and regulations to minimize potential risks to humans and the environment.

InChI:InChI=1/C9H12N2O4/c1-3-14-6-7(5-10)8(12)11-9(13)15-4-2/h6H,3-4H2,1-2H3,(H,11,12,13)/b7-6+

Upstream product

• 6629-04-5 ethyl N-cyanoacetylcarbamate 
• 122-51-0 orthoformic acid triethyl ester 
• 108-24-7 acetic anhydride 
• 1448-98-2 N-(aminocarbonyl)-2-cyano-acetamide 

Downstream Products

• 56673-29-1 (5-cyano-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetic acid 
• 58290-63-4 {(E)-3-[3-Chloro-4-(4-chloro-phenylsulfanyl)-phenylamino]-2-cyano-acryloyl}-carbamic acid ethyl ester 
• 58290-66-7 {(E)-2-Cyano-3-[3,5-dichloro-4-(4-chloro-phenylsulfanyl)-phenylamino]-acryloyl}-carbamic acid ethyl ester 
• 75837-80-8 α-cyano-β-(p-anisidino)-N-ethoxy-carbonylacrylamide 
• 95337-40-9 5-cyano-1-(2-hydroxy-2-phenylethyl)uracil 
• 126080-34-0 5-cyano-1-(p-methoxyphenyl)-3-methyluracil 
• 75837-81-9 1-(4-methoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 
• 126080-42-0 6-Amino-1-(4-methoxy-phenyl)-3-methyl-5-[(E)-methyliminomethyl]-1H-pyrimidine-2,4-dione 
• 126105-55-3 6-Amino-5-[(E)-cyclohexyliminomethyl]-1-(4-methoxy-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 
• 95361-57-2 6-cyano-2,3-dihydro-7-oxo-2-phenyl-7H-oxazolo<3,2-a>pyrimidine 
• 95337-55-6 5-amino-6-cyclohexyliminomethyl-3-ethyl-2,3-dihydro-7-oxo-7H-oxazolo<3,2-a>pyrimidine 
• 95337-57-8 5-amino-6-benzyliminomethyl-3-ethyl-2,3-dihydro-7-oxo-7H-oxazolo<3,2-a>pyrimidine 
• 95337-46-5 5-cyano-1-(1-ethyl-2-tosyloxyethyl)uracil 
• 75837-73-9 5-cyano-1-(2,6-dimethylphenyl)uracil 

Relevant academic research and scientific papers

A multi-component reaction to 5-cyanouracils: Synthesis and mechanistic study

Acetonitrile as a solvent, excess of primary amines as general bases, and a reflux condition make the multi-component reactions of (2-cyanoacetyl) carbamate 1, ethyl orthoformate, and primary amines form 5-cyanouracils 4a-c feasibly. Mechanistic studies o

Janus-AT bases: Synthesis, self-assembly, and solid state structures

The high yielding synthesis of heterocycles with defined H-bond accepting and donating capabilities provides for the design of self-assembling structures and specific recognition of biological targets. Herein we report the syntheses and solid-state structures of three self-complementary uracil/thymine derivatives where each presents the standard ADA face inherently complementary to adenine and a synthetically appended DAD face complementary to uracil/thymine. These heterocycles, which have never before been reported or characterized, represent diaminopurine-uracil/thymine hybrids that, in two of the three cases, relate to previously reported heterocyclic hybrids of G and C. All three heterocycles crystallized to afford the first X-ray crystal structures of self-complementary heterocycles capable of ADA-DAD pairing. The potential use in DNA and RNA recognition are briefly discussed.

Why is the reaction of ethyl (2-cyanoacetyl)carbamate with ethyl orthoformate highly stereoselective?

The reaction of ethyl (2-cyanoacetyl)carbamate (1) with ethyl orthoformate in the presence of acetic anhydride is highly stereoselective and only E-ethyl (2-cyano-3-ethoxyacryloyl)carbamate (E-2) is isolated. The reaction is thermodynamically controlled and the product distribution depends on the relative stability between E-2 and Z-2. Both the resonance stabilization of 1.47 kcal mol-1 and the steric hindrance of 2.28 kcal mol-1 in favour of E-2 contribute to the relative stability (3.75 kcal mol-1) between Z-2 and E-2, which is calculated from four isodesmic reactions, and this is the reason why the reaction of compound 1 with ethyl orthoformate is highly stereoselective. The electron-withdrawing ability of some substituents was evaluated. The sequence of π-accepting ability is C(O)NHC(O)OEt > C(O)NH2 > CN and the sequence of σ-accepting ability is CN > C(O)NHC(O)OEt > C(O)NH2. Copyright

THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF

Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.

AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS

The present invention relates to novel compounds of formula (I)' or a salt thereof: wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11 -membered heteroaryl bicyclic group; A is a group P

Pyrimidine derivatives useful as inhibitors of PKC-theta

Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

α-Cyano-β-(trisubstituted phenylhydrazino)-n-ethoxycarbonylacrylamides

Novel 1-substituted pyrimidinediones and thiopyrimidineones, synthesis thereof and intermediates therefor, useful as control agents for pests.

1-Phenyl-3-polyhaloalkyl(vinyl)sulfenyl uracils

Novel 1-phenyl-3-polyhaloalkyl or polyhalovinyl uracils, and synthesis thereof, which are useful biological agents.

Phenyl uracils

Phenyl uracils, synthesis and intermediates therefor, and compositions for the control of pests, especially fungi and bacteria.

Pesticidal compositions and processes for treating plants

A method and pesticidal composition for the preventative, protectant, prophylactic and eradicant treatment of plant fungi and bacteria comprises applying an effective amount to plants or seeds of a pesticidal composition containing in an inert carrier a c