1187055-91-9

Upstream product

• 1187055-90-8 2-(5-(3-aminopyridin-4-yl)-3,3-dimethylcyclohexyl)isoindoline-1,3-dione 
• 1187055-86-2 5,5-dimethyl-3-(3-nitropyridin-4-yl)cyclohex-2-enone 
• 1187055-87-3 5,5-dimethyl-3-(3-nitropyridin-4-yl)cyclohex-2-enol 
• 497959-45-2 1-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-5,5-dimethylcyclohex-1-en-3-one 
• 76881-19-1 5,5-dimethyl-3-trifluoromethylsulfonyloxycyclohex-2-en-1-one 
• 126-81-8 dimedone 
• 13091-23-1 4-chloro-3-nitropyridine 
• 1187055-88-4 2-(5,5-dimethyl-3-(3-nitropyridin-4-yl)-cyclohex-2-enyl)isoindoline-1,3-dione 
• 1187055-89-5 2-(3-(3-aminopyridin-4-yl)-5,5-dimethyl-cyclohex-2-enyl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

Kinase inhibitors and methods of their use

New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.

Pim kinase inhibitors and methods of their use

The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.

PIM KINASE INHIBITORS AND METHODS OF THEIR USE

The present invention relates to new compounds of Formulas (I) and (II), their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmac