118715-08-5 Usage
General Description
"(8-(methyldithio)-1-naphthyl)methyl-8-amino-2,6-anhydro-3,8-dideoxyoctonate" is a complex chemical compound with a long and specific name. It is a derivative of naphthalene and contains an amino group and a dideoxyoctonate moiety. The presence of the methyldithio group and the specific arrangement of the atoms in the compound give it unique chemical properties and potential applications in various fields such as pharmaceuticals, organic synthesis, and materials science. Further study and research are needed to fully understand the properties and potential uses of this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 118715-08-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,7,1 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 118715-08:
(8*1)+(7*1)+(6*8)+(5*7)+(4*1)+(3*5)+(2*0)+(1*8)=125
125 % 10 = 5
So 118715-08-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H25NO6S2/c1-28-29-16-7-3-5-11-4-2-6-12(17(11)16)10-26-20(25)15-8-13(22)18(24)19(27-15)14(23)9-21/h2-7,13-15,18-19,22-24H,8-10,21H2,1H3/t13-,14-,15+,18-,19-/m1/s1
118715-08-5Relevant articles and documents
A Novel Prodrug of an Impermeant Inhibitor of 3-Deoxy-D-manno-2-octulosonate Cytidylyltransferase Has Antibacterial Activity
Norbeck, Daniel W.,Rosenbrook, William,Kramer, James B.,Grampovnik, David J.,Lartey, Paul A.
, p. 625 - 629 (1989)
Although 8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonic acid (2) is a potent inhibitor of 3-deoxy-D-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase), it is unable to reach its cytoplasmic target and is therefore inactive as an antibacterial agent.However, esterification of 2 with 8-(hydroxymethyl)-1-naphthyl methyl disulfide (8) generates a prodrug (12), which gains entry into bacterial cells.Intracellular reduction of the disulfide leads to a rapid, intramolecular, displacement of the acid 2, which then inhibits the growth of Gram-negative bacteria by interfering with the biosynthesis of lipopolysaccharide.
