1187209-18-2 Usage
Uses
Used in Pharmaceutical Industry:
2-(4-Boronophenyl)-2-methylpropanoic acid is used as a reagent for the synthesis of inhibitors targeting serum and glucocorticoid-related kinase 1 (SGK1). SGK1 is a protein kinase that plays a role in various cellular processes, including cell survival, proliferation, and ion transport. Inhibiting SGK1 has been shown to have potential therapeutic benefits in treating certain diseases and conditions.
The compound serves as a key building block in the development of SGK1 inhibitors, which can modulate the activity of this kinase and potentially lead to the discovery of new treatments for diseases where SGK1 plays a significant role. By incorporating 2-(4-Boronophenyl)-2-methylpropanoic acid into the molecular structure of these inhibitors, researchers can optimize their potency, selectivity, and pharmacokinetic properties, ultimately contributing to the advancement of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1187209-18-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,2,0 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1187209-18:
(9*1)+(8*1)+(7*8)+(6*7)+(5*2)+(4*0)+(3*9)+(2*1)+(1*8)=162
162 % 10 = 2
So 1187209-18-2 is a valid CAS Registry Number.
1187209-18-2Relevant academic research and scientific papers
Metabolically stable tert-butyl replacement
Barnes-Seeman, David,Jain, Monish,Bell, Leslie,Ferreira, Suzie,Cohen, Scott,Chen, Xiao-Hui,Amin, Jakal,Snodgrass, Brad,Hatsis, Panos
, p. 514 - 516 (2013/07/26)
Susceptibility to metabolism is a common issue with the tert-butyl group on compounds of medicinal interest. We demonstrate an approach of removing all the fully sp3 C-Hs from a tert-butyl group: replacing some C-Hs with C-Fs and increasing the s-character of the remaining C-Hs. This approach gave a trifluoromethylcyclopropyl group, which increased metabolic stability. Trifluoromethylcyclopropyl-containing analogues had consistently higher metabolic stability in vitro and in vivo compared to their tert-butyl-containing counterparts.
