1187209-18-2

Basic information

• Product Name: 2-(4-Boronophenyl)-2-methylpropanoic acid
• Synonyms: 2-(4-Boronophenyl)-2-methylpropanoic acid
• CAS NO: 1187209-18-2
• Molecular Formula: C₁₀H₁₃BO₄
• Molecular Weight: 208.01882
• Mol File: 1187209-18-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-Boronophenyl)-2-methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Boronophenyl)-2-methylpropanoic acid(1187209-18-2)
• EPA Substance Registry System: 2-(4-Boronophenyl)-2-methylpropanoic acid(1187209-18-2)

Safety Data

• Hazardous Substances Data: 1187209-18-2(Hazardous Substances Data)

Usage

Uses

2-(4-Boronophenyl)-2-methylpropanoic Acid is a reagent used in the synthesis of serum and glucocorticoid-related kinase 1 (SGK1) inhibitors.

Upstream product

• 121-43-7 Trimethyl borate 
• 32454-35-6 2-(4-bromophenyl)-2-methylpropionic acid 

Downstream Products

• 1431616-20-4 6-(4-(1-hydroxy-2-methylpropan-2-yl)phenyl)nicotinonitrile 

Relevant articles and documents

Metabolically stable tert-butyl replacement

Susceptibility to metabolism is a common issue with the tert-butyl group on compounds of medicinal interest. We demonstrate an approach of removing all the fully sp3 C-Hs from a tert-butyl group: replacing some C-Hs with C-Fs and increasing the s-character of the remaining C-Hs. This approach gave a trifluoromethylcyclopropyl group, which increased metabolic stability. Trifluoromethylcyclopropyl-containing analogues had consistently higher metabolic stability in vitro and in vivo compared to their tert-butyl-containing counterparts.