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2-(4-Bromophenyl)-2-methylpropionic acid Manufacturer/High quality/Best price/In stock
Cas No: 32454-35-6
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
2-(4-bromophenyl)-2-methylpropanoic acid
Cas No: 32454-35-6
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
2-(4-Bromophenyl)-2-methylpropionic acid
Cas No: 32454-35-6
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
32454-35-6 2-(4-Bromo-phenyl)-2-methyl-propionic acid
Cas No: 32454-35-6
No Data 1 Kilogram 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
Factory direct supply CAS 32454-35-6 with best quality
Cas No: 32454-35-6
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
High Purity 2-(4-Bromophenyl)-2-methylpropionic acid Cas No: 32454-35-6
Cas No: 32454-35-6
USD $ 1.0-3.0 / Gram 10 Gram 1000 Kilogram/Month Wuhan Monad Medicine Tech Co.,LTD Contact Supplier
2-(4-Bromophenyl)-2-methylpropionic acid
Cas No: 32454-35-6
No Data No Data No Data Shandong Hanjiang Chemical Co., Ltd. Contact Supplier
2-(4-Bromophenyl)-2-Methylpropionic Acid
Cas No: 32454-35-6
No Data No Data No Data Xiamen Hisunny Chemical Co.,Ltd Contact Supplier
32454-35-6 2-(4-Bromophenyl)-2-methylpropionic acid
Cas No: 32454-35-6
USD $ 1.0-1.0 / Kilogram 1 Kilogram 100 Kilogram/Week Career Henan Chemical Co Contact Supplier
2-(4-BROMOPHENYL)-2-METHYLPROPANOIC ACID
Cas No: 32454-35-6
No Data 1 Gram 1000 Gram/Week Shanghai BetterBioChem Co., Ltd. Contact Supplier

32454-35-6 Usage

Chemical Properties

White Solid
InChI:InChI=1/C10H11BrO2/c1-10(2,9(12)13)7-3-5-8(11)6-4-7/h3-6H,1-2H3,(H,12,13)

32454-35-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-bromophenyl)-2-methylpropanoic acid

1.2 Other means of identification

Product number -
Other names 2-Methyl-2-(4-bromophenyl) propionic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:32454-35-6 SDS

32454-35-6Synthetic route

2-(4-bromophenyl)-2-methylpropanenitrile
101184-73-0

2-(4-bromophenyl)-2-methylpropanenitrile

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 80 - 85℃; for 18h; Hydrolysis;99%
With water; potassium hydroxide In ethanol for 20h; Reflux;5.3 g
With potassium hydroxide In ethylene glycol for 4h; Reflux;
1-bromo-4-(2-isocyanopropan-2-yl)benzene

1-bromo-4-(2-isocyanopropan-2-yl)benzene

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 100℃; for 16h;99%
methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: methyl 2-(4-bromophenyl)-2,2-dimethylacetate With water; lithium hydroxide In 1,4-dioxane at 50℃; for 5.5h;
Stage #2: With hydrogenchloride In 1,4-dioxane; water
94%
Stage #1: methyl 2-(4-bromophenyl)-2,2-dimethylacetate With methanol; lithium hydroxide; water In tetrahydrofuran at 0 - 20℃; for 3h;
Stage #2: With hydrogenchloride In water at 0℃;
Stage #1: methyl 2-(4-bromophenyl)-2,2-dimethylacetate With potassium hydroxide; ethanol; water at 90℃; for 15h;
Stage #2: With hydrogenchloride; water pH=2.0;
C15H20BrClO2

C15H20BrClO2

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With water; sodium hydroxide In methanol for 2h; Reflux;86%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: 2-methyl-2-phenylpropionic acid With bromine; sodium carbonate In water at 25 - 30℃; pH=7;
Stage #2: With hydrogenchloride In water pH=1 - 2; Product distribution / selectivity;
81%
Stage #1: 2-methyl-2-phenylpropionic acid With bromine; sodium hydrogencarbonate In water at 25 - 35℃; for 13h; Industry scale;
Stage #2: With hydrogenchloride In water at 0 - 10℃; pH=5; Product distribution / selectivity;
46.6%
With tetrachloromethane; bromine; iron
Ethyl 4-bromophenylacetate
14062-25-0

Ethyl 4-bromophenylacetate

methyl iodide
74-88-4

methyl iodide

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With sodium hydride
2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester
32454-36-7

2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With methanol; sodium hydroxide; water In tetrahydrofuran at 20℃; for 16h;
Stage #1: 2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester With methanol; potassium hydroxide; water at 0℃; for 2h; Heating / reflux;
Stage #2: With hydrogenchloride; methanol In water
potassium trimethylsilonate
10519-96-7

potassium trimethylsilonate

methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran
benzene
71-43-2

benzene

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / Industry scale
2.1: sodium hydrogencarbonate; bromine / water / 13 h / 25 - 35 °C / Industry scale
2.2: 0 - 10 °C / pH 5
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / Industry scale
2.1: bromine; sodium carbonate / water / 25 - 30 °C / pH 7
2.2: pH 1 - 2
View Scheme
2-(4-bromophenyl)propionic acid
53086-53-6

2-(4-bromophenyl)propionic acid

methyl iodide
74-88-4

methyl iodide

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)propionic acid With lithium diisopropyl amide In tetrahydrofuran at 45℃; for 1h; Inert atmosphere; Cooling with ice;
Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
(4-bromo-phenyl)-acetic acid methyl ester
41841-16-1

(4-bromo-phenyl)-acetic acid methyl ester

methyl iodide
74-88-4

methyl iodide

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester; methyl iodide With sodium hydride
Stage #2: With potassium hydroxide
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2,2-dimethyl-2-(4-bromophenyl)ethanol
32454-37-8

2,2-dimethyl-2-(4-bromophenyl)ethanol

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With borane-THF In tetrahydrofuran at 0 - 20℃;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
100%
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride In diethyl ether at -78 - 23℃;
With lithium aluminium tetrahydride In diethyl ether at 20℃; Inert atmosphere;
methanol
67-56-1

methanol

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Conditions
ConditionsYield
With sulfuric acid; acetonitrile at 80 - 85℃; for 16 - 18h;98%
With sulfuric acid In toluene at 63 - 67℃; for 16h; Industry scale;79%
With sulfuric acid In toluene at 63 - 67℃; for 16h; Industry scale;79%
tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Conditions
ConditionsYield
With sulfuric acid Reflux; regioselective reaction;93%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl N-[1-(4-bromophenyl)-1-methylethyl]carbamate
578729-08-5

benzyl N-[1-(4-bromophenyl)-1-methylethyl]carbamate

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With diphenyl phosphoryl azide; triethylamine In toluene for 4h; Reflux;
Stage #2: benzyl alcohol In toluene Reflux;
69%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-(4-bromophenyl)propan-2-ol
2077-19-2

2-(4-bromophenyl)propan-2-ol

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; water; tert-butylammonium hexafluorophosphate(V) In acetone at 20℃; for 3h; Electrolysis;67%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-propenal

3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-propenal

2-(4-{3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-1-hydroxy-allyl}-phenyl)-2-methyl-propionic acid

2-(4-{3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-1-hydroxy-allyl}-phenyl)-2-methyl-propionic acid

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With sodium hydride In tetrahydrofuran deprotonation;
Stage #2: With tert.-butyl lithium In tetrahydrofuran at -72℃; Metallation;
Stage #3: 3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-propenal In tetrahydrofuran at -72℃; Condensation;
65%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid
909187-36-6

2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In dimethyl sulfoxide at 80℃; Inert atmosphere;63%
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 80℃; for 18h;
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

6-bromo-3,3-dimethylbenzofuran-2(3H)-one
1418028-03-1

6-bromo-3,3-dimethylbenzofuran-2(3H)-one

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; potassium acetate; palladium diacetate; N-acetylglycine In tert-butyl alcohol at 100℃; for 12h; Sealed tube;63%
With isopropylmagnesium bromide; triphenylphosphine; cobalt(II) chloride In tetrahydrofuran at 20℃; for 18h; Green chemistry;41%
With [bis(acetoxy)iodo]benzene; palladium diacetate; potassium carbonate; N-acetylglycine In tert-butyl alcohol at 100℃; for 20h; Inert atmosphere;26%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde
105955-84-8

4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde

fexofenadine
83799-24-0

fexofenadine

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With sodium hydride In tetrahydrofuran at 25℃; for 0.5h; deprotonation;
Stage #2: With tert.-butyl lithium In tetrahydrofuran at -72℃; for 0.916667h; Metallation;
Stage #3: 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde In tetrahydrofuran at -72℃; for 2.5h; Condensation;
60%
1,2,3-triazole
288-36-8

1,2,3-triazole

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-(2-(4-bromophenyl)propan-2-yl)oxazole
1236409-17-8

2-(2-(4-bromophenyl)propan-2-yl)oxazole

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h;
Stage #2: 1,2,3-triazole With potassium carbonate In sulfolane at 120℃; for 1h;
43%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

trans-β-chloroacrylonitrile
871-29-4, 3721-37-7, 3721-38-8

trans-β-chloroacrylonitrile

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-2-methylpropionic acid
1356089-38-7

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With phenyllithium In tetrahydrofuran; toluene at -80℃; for 0.0833333h; Inert atmosphere;
Stage #2: With n-butyllithium In tetrahydrofuran; hexane; toluene for 0.333333h; Inert atmosphere;
Stage #3: trans-β-chloroacrylonitrile Further stages;
43%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

4-(1-hydroxy-2-methylpropan-2-yl)benzoic acid
75492-21-6

4-(1-hydroxy-2-methylpropan-2-yl)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4; diethyl ether
2: butyl lithium; diethyl ether / anschliessend Behandeln mit CO2
View Scheme
(S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-(((S)-2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)amino)pentanamide
847358-99-0

(S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-(((S)-2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)amino)pentanamide

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

4'-[(1S)-1-[[(1S)-1-[[(1-cyanocyclopropyl)amino]carbonyl]-3-fluoro-3-methylbutyl]amino]-2,2,2-trifluoroethyl]-α,α-dimethyl-[1,1'-biphenyl]-4-acetic acid

4'-[(1S)-1-[[(1S)-1-[[(1-cyanocyclopropyl)amino]carbonyl]-3-fluoro-3-methylbutyl]amino]-2,2,2-trifluoroethyl]-α,α-dimethyl-[1,1'-biphenyl]-4-acetic acid

Conditions
ConditionsYield
With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In DMF (N,N-dimethyl-formamide); water at 80℃; for 3h;
trans-4-aminoadamantan-1-carboxylic acid methyl ester hydrochloride

trans-4-aminoadamantan-1-carboxylic acid methyl ester hydrochloride

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

E-4-[2-(4-bromo-phenyl)-2-methyl-propionylamino]-adamantane-1-carboxylic acid methyl ester

E-4-[2-(4-bromo-phenyl)-2-methyl-propionylamino]-adamantane-1-carboxylic acid methyl ester

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-(4-bromophenyl)-2-methylpropanoic acid chloride
1040860-77-2

2-(4-bromophenyl)-2-methylpropanoic acid chloride

Conditions
ConditionsYield
With thionyl chloride for 2h; Heating / reflux;
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

C24H34O3Si

C24H34O3Si

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / diethyl ether / -78 - 23 °C
2.1: 1H-imidazole / dichloromethane / 23 °C
3.1: n-butyllithium / tetrahydrofuran / -78 °C
3.2: 23 °C
4.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane / 100 °C
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

C22H39BO3Si
1322094-75-6

C22H39BO3Si

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / diethyl ether / -78 - 23 °C
2.1: 1H-imidazole / dichloromethane / 23 °C
3.1: n-butyllithium / tetrahydrofuran / -78 °C
3.2: 23 °C
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

C23H32O3Si
1322094-76-7

C23H32O3Si

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / diethyl ether / -78 - 23 °C
2.1: 1H-imidazole / dichloromethane / 23 °C
3.1: n-butyllithium / tetrahydrofuran / -78 °C
3.2: 23 °C
4.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane / 100 °C
5.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 23 °C
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-prop-2-ynylisobutyramide
1365091-34-4

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-prop-2-ynylisobutyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: phenyllithium / tetrahydrofuran; toluene / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h / Inert atmosphere
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h
1.3: 0.25 h
2.1: acetic acid / water; methanol / 20 °C
2.2: 1 h
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

(E)-3-{4-[1,1-dimethyl-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-benzenesulfonyl}acrylonitrile
1365091-28-6

(E)-3-{4-[1,1-dimethyl-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-benzenesulfonyl}acrylonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: phenyllithium / tetrahydrofuran; toluene / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h / Inert atmosphere
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h
1.3: 0.25 h
2.1: acetic acid / water; methanol / 20 °C
2.2: 1 h
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide
1365091-35-5

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: phenyllithium / tetrahydrofuran; toluene / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h / Inert atmosphere
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h
1.3: 0.25 h
2.1: acetic acid / water; methanol / 20 °C
2.2: 1 h
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C
View Scheme

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