1187305-02-7Relevant articles and documents
Heavier group 2 metals and intermolecular hydroamination: A computational and synthetic assessment
Barrett, Anthony G. M.,Brinkmann, Christine,Crimmin, Mark R.,Hill, Michael S.,Hunt, Patricia,Procopiou, Panayiotis A.
, p. 12906 - 12907 (2009)
(Chemical Equation Presented) A density functional theory assessment of the use of the group 2 elements Mg, Ca, Sr, and Ba for the intermolecular hydroamination of ethene indicated that the efficiency of the catalysis is dependent upon both the polarity and the deformability of the electron density within the metal-substituent bonds of key intermediates and transition states. The validity of this analysis was supplemented by a preliminary study of the use of group 2 amides for the intermolecular hydroamination of vinyl arenes. Although strontium was found to provide the highest catalytic activity, in line with the expectation provided by the theoretical study, a preliminary kinetic analysis demonstrated that this is possibly a consequence of the increased radius and accessibility of this cation rather than a reflection of a reduced barrier for rate-determining alkene insertion.
Iridium-catalyzed decarboxylative N-alkylation of α-amino acids with primary alcohols
Wu, Jiashou,Jiang, Huajiang,Chen, Dingben,Shen, Jianfen,Zhao, Datong,Xiang, Jing,Zhou, Qizhong
, p. 539 - 542 (2014/03/21)
A new decarboxylative N-alkylation reaction of α-amino acids has been developed. A variety of tertiary amines were obtained in good to excellent yields via the decarboxylative N-alkylation reaction of α-amino acids with primary alcohols catalyzed by a CpIr complex. Georg Thieme Verlag Stuttgart New York.
Anti-markovnikov hydroamination of aromatic alkenes with secondary amines catalyzed by easily accessible yttrium complexes
Germain, Stephane,Schulz, Emmanuelle,Hannedouche, Jerome
, p. 2065 - 2073 (2014/08/05)
Binaphthylamido alkyl yttrium complexes have been proven to promote the anti-Markovnikov addition between various styrene derivatives and secondary amines efficiently. Although the reaction has to be performed at high temperature, it is realized advantage
A chiral phenoxyamine magnesium catalyst for the enantioselective hydroamination/cyclization of aminoalkenes and intermolecular hydroamination of vinyl arenes
Zhang, Xiaoming,Emge, Thomas J.,Hultzsch, Kai C.
supporting information; experimental part, p. 394 - 398 (2012/03/22)
If Grignard had only known! A chiral magnesium complex catalyzes the intramolecular hydroamination/cyclization of aminoalkenes with high efficiency at temperatures as low as -20 °C and enantioselectivities as high as 93 %ee. The high activity of this system also allows the catalytic intermolecular anti-Markovnikov addition of pyrrolidine and benzylamine to vinyl arenes. Copyright
