1187357-11-4Relevant academic research and scientific papers
Ruthenium-catalyzed hydroamination of aminoallenes: An approach to vinyl substituted heterocycles
Broggini, Gianluigi,Poli, Giovanni,Beccalli, Egle M.,Brusa, Filippo,Gazzola, Silvia,Oble, Julie
, p. 677 - 682 (2015)
Heterosubstituted aminoallenes underwent smooth ruthenium-catalyzed intramolecular exo-hydroamination reactions yielding the corresponding five-, six-, or seven-membered 1,3-diaza- or 1,3-oxaza-heterocyclic structures. This procedure is a valuable and less expensive alternative to the already known transition metal-catalyzed hydroamination reactions of aminoallenes.
Novel camptothecin derivative, and preparation method and application thereof
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Paragraph 0179-0180; 0183, (2020/03/12)
The invention relates to a novel camptothecin derivative and application thereof, a tumor cell growth inhibitor, a ternary complex, and a method for improving the solubility of the camptothecin derivative. The camptothecin derivative is formed by modifying a substance represented by formula I through glycosylated triazole in the position R3. In a structural formula represented by the formula I, R1represents H, alkyl of C1-10, deuterated alkyl of the C1-10, or halogenated alkyl of the C1-10; R2 represents H, CH2N(CH3)2 or CH2N(CD3)2; R4 represents H, and X represents N, O or S; L represents polypeptide, C1-20 linear alkyl or a derivative thereof, a C1-20 linear or branched acyl derivative, or C2-100 ethylene glycol or a derivative thereof. The camptothecin derivative has high solubility, prepared anticancer drugs have the advantages of wide anticancer spectrum and high safety, and the in-vivo anticancer activity is superior to that of irinotecan hydrochloride.
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00962; 001476; 001477, (2020/06/19)
The present invention provides compounds, compositions thereof, and methods of using the same.
IRAK DEGRADERS AND USES THEREOF
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Paragraph 3571; 3572, (2019/07/10)
The present invention provides compounds, compositions thereof, and methods of using the same.
PEPTIDE NUCLEIC ACID DERIVATIVES WITH GOOD CELL PENETRATION AND STRONG AFFINITY FOR NUCLEIC ACID
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Page/Page column 29-30, (2009/10/22)
The present invention provides a novel class of peptide nucleic acid derivatives, which show good cell penetration and strong binding affinity for nucleic acid.
