118753-66-5Relevant articles and documents
Oxadiazole derivative, preparation method and applications thereof
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Paragraph 0099; 0100; 0103; 0104, (2020/05/30)
The invention relates to an oxadiazole derivative, a preparation method and applications thereof, wherein the oxadiazole derivative has a structure represented by a formula (I), and R1, X and R2 are defined in the specification.
Solid dispersions containing an apoptosis-inducing agent
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, (2019/03/15)
A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY
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Paragraph 0286, (2019/12/28)
The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.