118757-41-8

Upstream product

• 118757-40-7 5-(4-Nitro-phenyl)-7-phenyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine 
• 555-16-8 4-nitrobenzaldehdye 
• 98-86-2 acetophenone 
• 61-82-5 3-amino-1,2,4-triazole 
• 20432-02-4 1-(4-nitro-phenyl)-3-phenyl-propenone 

Relevant academic research and scientific papers

Triazolopyrimidines: Synthesis of aryl-1,2,4-triazolo[1,5-a]pyrimidines by Doebner-Miller reaction and their antibacterial activity

Novel aryl-1,2,4-triazolo[1,5-a]pyrimidines (3-23) were prepared in good yields from corresponding 3-amino-1,2,4-triazoles by employing Doebner-Miller reaction. In some reactions intermediate dihydro products (3, 7, 17, 19, 23) were also isolated and identified. These compounds showed only mild antibacterial activity.

Cyclocondensation of α,β-Unsaturated Ketones with 3-Amino-1,2,4-Triazole

Dihydro-1,2,4-triazolopyrimidine derivatives were obtained by condensation of 3-amino-1,2,4-triazole with 1,3-diaryl-1-propen-3-ones.The structure of 5-phenyl-7-(4-methylphenyl)-4,7-dihydro-1,2,4-triazolopyrimidine was established by x-ray diffraction analysis.