1187586-61-3 Usage
Description
Montelukast Bis-sulfide (Mixture of Diastereomers) is a pale yellow solid that is an impurity of Montelukast and is a part of the diastereomer mixture Montelukast Bis-Sulfide (M567985). It is also known as Montelukast EP Impurity D and Montelukast USP Related Compound C.
Uses
Used in Pharmaceutical Industry:
Montelukast Bis-sulfide (Mixture of Diastereomers) is used as a Montelukast impurity in the pharmaceutical industry. It is important to monitor and control the levels of this impurity in Montelukast to ensure the safety and efficacy of the drug.
Check Digit Verification of cas no
The CAS Registry Mumber 1187586-61-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,5,8 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1187586-61:
(9*1)+(8*1)+(7*8)+(6*7)+(5*5)+(4*8)+(3*6)+(2*6)+(1*1)=203
203 % 10 = 3
So 1187586-61-3 is a valid CAS Registry Number.
1187586-61-3Relevant articles and documents
Identification, synthesis and characterization of impurities of Montelukast sodium
Sunil Kumar,Anjaneyulu,Hima Bindu
, p. 4536 - 4546 (2012/02/04)
Montelukast sodium is a selective leukotriene receptor antagonist which inhibits cysteinyl leukotriene CysLT1 receptor. Various synthesis of Montelukast is published. During laboratory optimization and later in bulk synthesis formation of various impurities was detected. Besides, pharma Europa draft mention nine process related impurities. However, the method of preparation of most of these impurities is not available in literature. Also, different route of synthesis will have different impurity profile and those process related impurities are not covered in pharmacopeias. In this study we report the synthesis of possible process impurities, including seven impurities (A-H) mentioned in pharma Europa.