118764-13-9

Basic information

• Product Name: C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE
• Synonyms: C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE;1H-Tetrazole-5-MethanaMine, Monohydrochloride;5-TetrazoleMethanaMine Hydrochloride;5-(Aminomethyl)tetrazole monohydrochloride;(2H-tetrazol-5-yl)methanamine hydrochloride
• CAS NO: 118764-13-9
• Molecular Formula: C₂H₅N₅*ClH
• Molecular Weight: 0
• Mol File: 118764-13-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 143℃
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE(118764-13-9)
• EPA Substance Registry System: C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE(118764-13-9)

Safety Data

• Hazardous Substances Data: 118764-13-9(Hazardous Substances Data)

Usage

Description

C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE is a tetrazole derivative chemical compound that serves as an intermediate in the synthesis of pharmaceuticals. It is known for its potential biological activities due to the tetrazole ring, which acts as a bioisostere of carboxylic acids, allowing it to mimic their effects in biological systems. The hydrochloride salt form of this compound enhances its solubility and ease of handling in laboratory settings.

Uses

Used in Pharmaceutical Industry:
C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE is used as a synthetic intermediate for the development of various pharmaceuticals, including antihypertensive drugs and other biologically active compounds. Its tetrazole ring provides unique properties that can be leveraged in drug design to improve efficacy and pharmacokinetics.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE is utilized as a key component in the synthesis of new drugs and biologically active molecules. Its presence in these compounds can contribute to their biological activity, making it a valuable tool for researchers in drug discovery and development.
Used in Research and Development:
C-(2H-TETRAZOL-5-YL)-METHYLAMINE HYDROCHLORIDE is employed in research and development settings, particularly within the pharmaceutical industry, to explore its potential applications in the synthesis of novel drugs and other therapeutic agents. Its hydrochloride salt form facilitates its use in laboratory processes, making it a preferred choice for researchers working on drug synthesis and optimization.

Upstream product

• 119851-20-6 (6RS,13RS)-5H,12H-6,13-Methano-7H,14H-ditetrazolo<1,5-c:1',5'-h><1,3,6,8>tetrazecin 
• 112273-70-8 N-((1H-tetrazol-5-yl)methyl)benzamide 
• 1340483-79-5 benzhydryl-[1-(1,1,3,3-tetramethylbutyl)-1H-tetrazol-5-ylmethyl]amine 

Downstream Products

• 1220897-94-8 C₂₈H₃₁Cl₂N₇O₂ 
• 31602-63-8 (1H-tetrazol-5-yl)methanamine 
• 1427588-75-7 C₂₁H₂₁ClN₈O*C₂HF₃O₂ 

Relevant articles and documents

Cleavable β-Cyanoethyl Isocyanide in the Ugi Tetrazole Reaction

β-Cyanoethyl isocyanide is introduced as a cleavable isocyanide in the Ugi tetrazole reaction. Eleven examples are described that exhibit a broad scope and are obtained in good overall yields. The obtained 1H-tetrazole scaffold is an important bioisostere for carboxylic acids, and the method described here is a valuable alternative route to known procedures.

Design, Synthesis, and in Vitro and in Vivo Evaluation of an 18F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer

Sphingosine 1-phosphate receptor 1 (S1P1) plays a pivotal signaling role in inflammatory response; because S1P1 modulation has been identified as a therapeutic target for various diseases, a PET tracer for S1P1 would be a useful tool. Fourteen fluorine-containing analogues of S1P ligands were synthesized and their in vitro binding potency measured; four had high potency and selectivity for S1P1 (S1P1 IC50 100-fold selectivity for S1P1 over S1P2 and S1P3). The most potent ligand, 28c (IC50 = 2.63 nM for S1P1) was 18F-labeled and evaluated in a mouse model of LPS-induced acute liver injury to determine its S1P1-binding specificity. The results from biodistribution, autoradiography, and microPET imaging showed higher [18F]28c accumulation in the liver of LPS-treated mice than controls. Increased expression of S1P1 in the LPS model was confirmed by immunohistochemical analysis (IHC). These data suggest that [18F]28c is a S1P1 PET tracer with high potential for imaging S1P1 in vivo.

Aminomethyltetrazoles as potential inhibitors of the c-aminobutyric acid transporters mGAT1-mGAT4: Synthesis and biological evaluation

1,5-Disubstituted and 5-monosubstituted aminomethyltetrazole derivatives derived from glycine were synthesized employing a TMSN3-modified variant of the Ugi reaction as a key step. All compounds were evaluated regarding their inhibitory potency and subtype selectivity at the four murine GABA transporter subtypes mGAT1-mGAT4. Though none of the 5-monosubstituted tetrazoles turned out to inhibit [3H]GABA uptake to a significant extent, the 1,5-disubstituted tetrazole derivatives displayed a distinct activity, especially at the GABA transport proteins mGAT2-mGAT4. Thus, a reasonable potent and selective inhibitor of mGAT3 was found. Additionally, two more compounds were identified as potent inhibitors of mGAT2. This is especially relevant, as up to date only few potent inhibitors of mGAT2 that do not affect mGAT1 are known.