31602-63-8Relevant academic research and scientific papers
Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA)
Matthews, Hayden,Ranson, Marie,Tyndall, Joel D.A.,Kelso, Michael J.
scheme or table, p. 6760 - 6766 (2011/12/05)
A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K i = 7 μM), a promising anticancer target. Several studies have demonstrated significant antitum
SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF
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Page/Page column 250, (2009/04/25)
The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administeri
Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides
Sureshbabu, Vommina V.,Venkataramanarao, Rao,Naik, Shankar A.,Chennakrishnareddy
, p. 7038 - 7041 (2008/03/12)
An efficient synthesis of tetrazole analogues of amino acids starting from Nα-Fmoc amino acid in a three-step protocol is reported. The free amino tetrazoles were obtained in good yields and with excellent purity after removal of the Fmoc group
A Methanoditetrazolo-tetrazecine from 5-(Chloromethyl)tetrazole and Hexamethylenetetramine
Moderhack, Dietrich,Goos, Karl-Heinz,Preu, Lutz
, p. 689 - 690 (2007/10/02)
In contrast to N-substituted 5-(chloromethyl)tetrazoles (1; R = alkyl, aryl), the parent compound 1 (R = H) reacts with hexamethylenetetramine to give the methanoditetrazolo-tetrazecine 4, a rather unusual system.This compound which is also produced on reaction of 7 with formaldehyde occurs in the (6RS,13RS) form.
