1187648-24-3Relevant academic research and scientific papers
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors
Hu, Zilun,Wang, Cailan,Han, Wei,Rossi, Karen A.,Bozarth, Jeffrey M.,Wu, Yiming,Sheriff, Steven,Myers, Joseph E.,Luettgen, Joseph M.,Seiffert, Dietmar A.,Wexler, Ruth R.,Quan, Mimi L.
, p. 987 - 992 (2018/03/07)
Pyridazine and pyridazinone derivatives were designed and synthesized as coagulation factor XIa inhibitors. Potent and selective inhibitors with single digit nanomolar affinity for factor XIa were discovered. Selected inhibitors demonstrated moderate oral bioavailability.
