1187649-55-3Relevant academic research and scientific papers
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors
Hu, Zilun,Wang, Cailan,Han, Wei,Rossi, Karen A.,Bozarth, Jeffrey M.,Wu, Yiming,Sheriff, Steven,Myers, Joseph E.,Luettgen, Joseph M.,Seiffert, Dietmar A.,Wexler, Ruth R.,Quan, Mimi L.
, p. 987 - 992 (2018/03/07)
Pyridazine and pyridazinone derivatives were designed and synthesized as coagulation factor XIa inhibitors. Potent and selective inhibitors with single digit nanomolar affinity for factor XIa were discovered. Selected inhibitors demonstrated moderate oral bioavailability.
PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS
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Page/Page column 238-239, (2009/10/22)
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein the variables A, L1, L2, R2, R11, and M are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
