1187652-48-7Relevant articles and documents
Discovery of metal ions chelator quercetin derivatives with potent anti-HCV activities
Zhong, Dongwei,Liu, Mingming,Cao, Yang,Zhu, Yelin,Bian, Shihui,Zhou, Jiayi,Wu, Fengjie,Ryu, Kum-Chol,Zhou, Lu,Ye, Deyong
, p. 6978 - 6999 (2015/05/13)
Analogues or isosteres of α,γ-diketoacid (DKA) 1a show potent inhibition of hepatitis C virus (HCV) NS5B polymerase through chelation of the two magnesium ions at the active site. The anti-HCV activity of the flavonoid quercetin ( 2) could partly be attri
Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV)
Park, Hye Ri,Yoon, Hyunjun,Kim, Mi Kyoung,Lee, Sung Dae,Chong, Youhoon
, p. 77 - 85 (2012/07/03)
Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the
Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
Lee, Chaewoon,Lee, Jin Moo,Lee, Na-Ra,Kim, Dong-Eun,Jeong, Yong-Joo,Chong, Youhoon
experimental part, p. 4538 - 4541 (2010/04/03)
Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three c