118767-38-7Relevant academic research and scientific papers
Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols
Lamberto, Massimiliano,Corbett, David F.,Kilburn, Jeremy D.
, p. 1347 - 1349 (2003)
Alkenyl and alkynyl isocyanides were synthesised and then reacted, using microwave flash-heating technology, with thiophenol, 2-mercaptoethanol and ethanethiol, in the presence of a radical initiator, to give highly functionalised pyrrolines and pyroglutamates. Direct comparison with results obtained using traditional heating techniques showed the advantage of using the microwave technology in terms of faster reactions and better yields.
Histidyl peptide derivatives
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, (2008/06/13)
Novel peptide derivatives of the following formula STR1 wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof. Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.
