1187743-04-9

Basic information

• Product Name: N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]-2,2,2-trifluoroacetamide
• Synonyms: N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]-2,2,2-trifluoroacetamide
• CAS NO: 1187743-04-9
• Molecular Weight: 513.516
• Mol File: 1187743-04-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]-2,2,2-trifluoroacetamide(1187743-04-9)
• EPA Substance Registry System: N-[4-(3-{[6-(3,5-dimethylbenzyl)-5-ethyl-3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl]methoxy}prop-1-ynyl)phenyl]-2,2,2-trifluoroacetamide(1187743-04-9)

Safety Data

• Hazardous Substances Data: 1187743-04-9(Hazardous Substances Data)

Upstream product

• 126063-08-9 2,2,2-trifluoro-N-(4-iodophenyl)acetamide 
• 488702-38-1 6-(3,5-dimethyl-benzyl)-5-ethyl-1-prop-2-ynyloxymethyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 1187742-94-4 1-({[3-(4-aminophenyl)prop-2-ynyl]oxy}methyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil 

Relevant articles and documents

Synthesis and anti-HIV-1 evaluation of new Sonogashira-modified emivirine (MKC-442) analogues

The MKC-442 analogue 6-(3,5-dimethylbenzyl)-5-ethyluracil substituted with a (propargyloxo)-methyl group at N(1) has previously been found highly active against HIV-1. The C≡C bond in the substituent at N(1) is here utilized in a series of chemical reacti