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1187745-66-9

3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1187745-66-9 Structure

  • Basic information

    1. Product Name: 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one
    2. Synonyms: 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one
    3. CAS NO:1187745-66-9
    4. Molecular Formula:
    5. Molecular Weight: 405.494
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1187745-66-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one(1187745-66-9)
    11. EPA Substance Registry System: 3-hydroxy-5-ethyl-7,8-dimethoxy-2-(2-phenylpropyn-2-yl)-2,3-dihydro-1H-benzo[e]isoindol-1-one(1187745-66-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1187745-66-9(Hazardous Substances Data)

1187745-66-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1187745-66-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,7,4 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1187745-66:
(9*1)+(8*1)+(7*8)+(6*7)+(5*7)+(4*4)+(3*5)+(2*6)+(1*6)=199
199 % 10 = 9
So 1187745-66-9 is a valid CAS Registry Number.

1187745-66-9Relevant articles and documents

Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode

Zou, Haixia,Zhou, Liyan,Li, Yuanzhen,Cui, Yi,Zhong, Hanbing,Pan, Zhengying,Yang, Zhen,Quan, Junmin

experimental part, p. 994 - 1003 (2010/08/06)

Benzo[e]isoindole-1,3-dione derivatives were synthesized, and the effects on GSK-3β activity and zebrafish embryo growth were evaluated.Aseries of derivatives show obvious inhibitory activity against GSK-3β. The most potent inhibitor, 7,8-dimethoxy-5-methylbenzo[e]isoindole-1,3-dione (8a), shows nanomolar IC50 and obvious phenotype on zebrafish embryo growth associated with the inhibition of GSK-3β at low micromolar concentration. The interaction mode between 8a and GSK-3β was characterized by computational modeling. 2009 American Chemical Society.

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