1187831-33-9Relevant academic research and scientific papers
Synthesis and In vitro antimicrobial study of schiff base and thiazolidinone of 1-cyclopropyl-6-fluoro-7-[4-(2,3-dichlorophenyl)piperazin-1- yl]-4-quinolone
Patel, Navin B.,Patel, Sarvil D.
scheme or table, p. 45 - 53 (2010/08/19)
The title compounds, 2-substituted phenyl-3-{1-cyclopropyl-6-fluoro-7-[4- (2,3-dichlorophenylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline}carboxamido-1, 3-thiazolidin-4-ones 6a-j, have been synthesized after several structural variations viz. hydrazide 2 via acid chloride, Schiff base formation and cyclization of Schiff base followed by condensation with N-(2,3-dichlorophenyl) piperazine from the lead molecule 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4- dihydroquinolin-3-carboxylic acid 1. The synthesized compounds were tested for their antibacterial and antifungal activity (MIC) in vitro against organisms viz. S. aureus, S. pyogenes, E. coli, P. aeruginosa, C. albicans, A. niger and A. clavatus taking gentamycin, ampicillin, chloramphenicol, ciprofloxacin, norfloxacin, nystatin and greseofulvin as standard drugs. Compounds 4i, 5i and 6j (2-Cl, 2-Cl and 4-Cl) demonstrated excellent activity compared with ampicillin.
Synthesis and antimicrobial study of fluoroquinolonebased 4-thiazolidinones
Patel, Navin B.,Patel, Sarvil D.
experimental part, p. 757 - 770 (2011/12/04)
The title compounds 2-substituted phenyl-3-{1-cyclopropyl-6-fluoro- 7-[4-(4-methoxyphenylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline} carboxamido-1, 3-thiazolidin-4-ones 6a-j have been synthesized from lead molecule 7-chloro-1- cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1; this reacted with thionyl chloride to give acid chloride 2 and with hydrazine hydrate to afford hydrazide 3. The hydrazide 3 on condensation with substituted aromatic aldehydes a-j gave Schiff base; these on reaction with N-(4-methoxyphenyl) piperazine and thioglycolic acid furnished title compounds 6a-j. All of the synthesized compounds have been established by elemental analysis. IR and NMR spectral data and have been screened for antifungal and antibacterial activities. Birkhaeuser Boston 2009.
