118787-61-4

Usage

Uses

Used in Medicinal Chemistry:
[1,2,4]Triazolo[1,5-a]pyrimidine, 5,7-diphenylis used as a compound with potential biological activities for the development of new pharmaceuticals. Its unique structure may contribute to the discovery of novel therapeutic agents.
Used in Chemical Synthesis:
[1,2,4]Triazolo[1,5-a]pyrimidine, 5,7-diphenylserves as a building block for the synthesis of other organic compounds, expanding the scope of chemical diversity and potentially leading to the creation of new molecules with specific applications.
Used in Drug Discovery:
The unique structure and properties of [1,2,4]Triazolo[1,5-a]pyrimidine, 5,7-diphenylmake it a valuable candidate for drug discovery, where it can be further researched and optimized to develop new drugs with targeted therapeutic effects.
Used in Research and Development:
In the field of chemical synthesis and drug discovery, [1,2,4]Triazolo[1,5-a]pyrimidine, 5,7-diphenylis used as a subject of interest for research and development, potentially leading to advancements in understanding its properties and applications.

Upstream product

• 118757-35-0 5,7-diphenyl-4,7-dihydro-1,2,4-triazolo-<1,5-a>pyrimidine 
• 120-46-7 1,3-diphenylpropanedione 
• 61-82-5 3-amino-1,2,4-triazole 
• 39573-72-3 7-phenyl-1,2,4-triazolo<1,5-a>pyrimidine 
• 108-86-1 bromobenzene 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 
• 94-41-7 benzalacetophenone 

Downstream Products

• 263867-64-7 cis-[Pd(5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine)Cl₂]*H₂O 
• 1370010-01-7 cis-[PtI₂(NH₃)(5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine)] 
• 1370010-00-6 cis-[PtI₂(5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine)2] 
• 1370010-02-8 trans-[PtI₂(DMSO)(5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine)] 
• 220600-01-1 [Cu₂(CH₂ClCOO)4((C₆H₅)2C₅H₂N₄)2] 
• 193464-16-3 dichlorobis(5,7-diphenyl-1,2,4-triazolo[1,5-.alpha]pyrimidine)zinc(II) 
• 193464-17-4 dichlorobis(5,7-diphenyl-1,2,4-triazolo[1,5-.alpha]pyrimidine)cobalt(II) 
• 446235-01-4 trans-[PtCl₂(DMSO)(5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine] 

Relevant academic research and scientific papers

Synthesis of pyrimidine derivatives via multicomponent reaction catalyzed by ferric chloride

An eco-friendly and practical approach was developed for the synthesis of pyrimidine derivatives via a one-pot, three-component coupling reaction of commercially available aldehydes, alkynes, and indazole3/triazole catalyzed by ferric chloride with good to excellent yields. The advantages of this method include environmentally friendly catalyst, easily available materials, and ease of product isolation.

Direct (het)arylation of [1,2,4]triazolo[1,5-a]pyrimidines: Both eliminative and oxidative pathways

(Hetero)arylation of [1,2,4]triazolo[1,5-a]pyrimidine through the direct nucleophilic C[sbnd]H functionalization of the C-7 and C-5 positions has been implemented. The regioselective addition of a (het)aryl magnesium bromide to C-7 of 6-bromo-[1,2,4]triazolo[1,5-a]pyrimidine, followed by eliminative aromatization of the intermediate σH-adducts, has afforded 7-(hetero)aryl-substituted [1,2,4]triazolo[1,5-a]pyrimidines (the SNH reaction, proceeding according to the “addition-elimination” scheme). A second treatment with a Grignard reagent has resulted in the C-5 σH-adducts, which have been oxidized while being N-magnesium salts into [1,2,4]triazolo[1,5-a]pyrimidines, bearing various combinations of (hetero)aromatic substituents at C-5 and C-7 (the SNH process, realizing via the “addition-oxidation” scheme). As a result of optical and electrochemical studies, the obtained compounds have proved to be promising luminescent dyes and push-pull systems.

One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization

An efficient synthesis of nitrogen ring junction pyrimido-indazoles has been developed. This is a metal catalyzed transformation that proceeds via A3 coupling reaction between 1H-indazol-3-amine, aromatic aldehydes and alkynes, which undergoes

NMR Properties of 5,7-Disubstituted Derivatives of 1,2,4-Triazolopyrimidines

Some 5,7-disubstituted derivatives of 1,2,4-triazolopyrimidines with methyl, tert-butyl, phenyl and trifluoromethyl substituents were studied.The syntheses and 1H, 13C, 15N and 19F NMR and mass spectra are reported.Natural abundance 15N NMR spectra

CHEMICAL CONVERSIONS OF 5,7-DISUBSTITUTED DIHYDRO-1,2,4-TRIAZOLOPYRIMIDINES

Hydrolysis, oxidation, reduction, alkylation, and nitrosation of aromatic-substituted dihydro-1,2,4-triazolopyrimidines have been studied.

Cyclocondensation of α,β-Unsaturated Ketones with 3-Amino-1,2,4-Triazole

Dihydro-1,2,4-triazolopyrimidine derivatives were obtained by condensation of 3-amino-1,2,4-triazole with 1,3-diaryl-1-propen-3-ones.The structure of 5-phenyl-7-(4-methylphenyl)-4,7-dihydro-1,2,4-triazolopyrimidine was established by x-ray diffraction analysis.