118790-79-7

Upstream product

• 13304-62-6 N-benzylacrylamide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 705283-58-5 N-benzyl-2-bromo-3-methoxypropionamide 
• 175481-36-4 lacosamide 
• 175481-36-4 (2S)-2-(acetylamino)-N-benzyl-3-methoxypropanamide 
• 262845-82-9 N-Benzyl-2-Amino-3-Methoxypropionamide 
• 1379592-18-3 N-benzyl-2-azido-3-methoxy propionamide 
• 1379592-20-7 (R,S)-N-benzyl-2-benzylamino-3-methoxypropionamide 
• 1379592-19-4 2-amino-N-benzyl-3-methoxypropionamide monooxalate 

Relevant academic research and scientific papers

METHOD FOR PRODUCING N-BENZYL-2-BROMO-3-METHOXYPROPIONAMIDE AND INTERMEDIATES THEREOF

The present invention provides an industrially-preferable method for safely producing N-benzyl-2-bromo-3-methoxypropionamide at a high yield but at low cost. The method for producing of the present invention includes: in sequence, an amidation process that causes diacrylic anhydride to react with benzylamine in a solvent to obtain N-benzylacrylamide; a bromination process that causes N-benzylacrylamide to react with bromine in a solvent to obtain N-benzyl-2,3-dibromopropionamide; and a methoxylation process that causes N-benzyl-2,3-dibromopropionamide to react with methanol in the presence of a base to obtain N-benzyl-2-bromo-3-methoxypropionamide.

PROCESS FOR THE PREPARATION OF LACOSAMIDE

There is provided a process for the preparation of Lacosamide (which is a useful medicament) of formula I, which comprises an enantioselective enzymatic acylation.