13304-62-6Relevant academic research and scientific papers
Solid-phase synthesis of 2-alkenamides from polystyrene-supported α-selenocarboxylic acids
Liu, Xiao-Ling,Wang, Xing-Cong,Sheng, Shou-Ri
, p. 1303 - 1306 (2004)
The polystyrene-supported α-selenoacetic acid and α-selenopropionic acid were prepared and used for the synthesis of 2-alkenamides from primary and secondary amines in good yields and high purities.
Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity
Re?ing, Nina,Marquardt, Viktoria,Gertzen, Christoph G.W.,Sch?ler, Andrea,Schramm, Alexander,Kurz, Thomas,Gohlke, Holger,Aigner, Achim,Remke, Marc,Hansen, Finn K.
, p. 1109 - 1115 (2019)
Histone deacetylases (HDACs) have been identified as promising epigenetic drug targets for the treatment of neuroblastoma and glioblastoma. In this work, we have rationally designed a novel class of peptoid-based histone deacetylase inhibitors (HDACi). A
Ionic Liquid as a Suitable Phase for Multistep Parallel Synthesis of an Array of Isoxazolines
Rodriquez, Manuela,Sega, Alessandro,Taddei, Maurizio
, p. 4029 - 4031 (2003)
(Equation presented) A parallel array of isoxazoline diamides was prepared using an ionic liquid [bmim][BF4] as the phase where a three-step procedure (Schotten-Baumann, 1,3-dipolar cycloaddition, ester amidation with Me3Al) was carr
Dynamic Interfacial Adhesion through Cucurbit[n]uril Molecular Recognition
Liu, Ji,Tan, Cindy Soo Yun,Scherman, Oren A.
, p. 8854 - 8858 (2018)
Supramolecular building blocks, such as cucurbit[n]uril (CB[n])-based host–guest complexes, have been extensively studied at the nano- and microscale as adhesion promoters. Herein, we exploit a new class of CB[n]-threaded highly branched polyrotaxanes (HB
The phosphazo route to 2-alkenamides from acrylic acid and its derivatives
Cabral, Jose,Laszlo, Pierre,Montaufier, Marie-Therese,Lalatiana Randriamahefa
, p. 1705 - 1708 (1990)
2-Alkenamides are formed in good isolated yields (generally up to 70%) by the reaction of in situ-generated phosphazo compounds issued from aliphatic, alicyclic and aromatic primary amines, with acrylic acid and its derivatives.
Highly stereoselective cyclopropanation of α,β-unsaturated carbonyl compounds with methyl (diazoacetoxy)acetate catalyzed by a chiral ruthenium(II) complex
Chanthamath, Soda,Takaki, Suguru,Shibatomi, Kazutaka,Iwasa, Seiji
, p. 5818 - 5821 (2013)
Tantalizing triangles: The title reaction gives bicarbonyl cyclopropane products that can lead to versatile intermediates with high yields and stereoselectivities. This system was also applied to the enantioselective total synthesis of spiro cyclopropane oxindole, an HIV-1 nonnucleoside reverse transcriptase inhibitor. Copyright
Direct Photoredox-Catalyzed Reductive Difluoromethylation of Electron-Deficient Alkenes
Tang, Xiao-Jun,Zhang, Zuxiao,Dolbier, William R.
, p. 18961 - 18965 (2015)
Photoredox-catalyzed reductive difluoromethylation of electron-deficient alkenes was achieved in one step under tin-free, mild and neutral conditions. This protocol affords a facile method to introduce RCF2 (R=H, Ph, Me, and CH2N3) groups at sites β to electron-withdrawing groups. It was found that TTMS (tris(trimethylsilyl)silane) served nicely as both the H-atom donor and the electron donor in the catalytic cycle. Experimental and DFT computational results provided evidence that RCF2 (R=H, Ph, Me) radicals are nucleophilic in nature.
Selenium-linking strategy for traceless solid-phase synthesis of acrylamides
Sheng, Shou-Ri,Wang, Xing-Cong,Liu, Xiao-Ling,Song, Cai-Sheng
, p. 2867 - 2872 (2003)
A novel polystyrene-supported β-selenopropionic acid has been developed and applied to simple and efficient synthesis of acrylamides.
Retro-aza-Michael reaction of an o-aminophenol adduct in protic solvents inspired by natural products
Kakeya, Hideaki,Kaneko, Kensuke,Nishimura, Shinichi,Takahashi, Nobuaki,Takenaka, Kei
, (2021)
α,β-Unsaturated carbonyls are reactive group often found in bioactive small molecules. Their non-specific reaction with biomolecules can be the cause of the low efficacy and unexpected side-effects of the molecule. Accordingly, unprotected α,β-unsaturated carbonyls are not often found in drugs. Here, we report that o-aminophenol is a new masking group of α,β-unsaturated ketone, which is inspired by natural products saccharothriolides. o-Aminophenol adduct of α,β-unsaturated ketone, but not those of α,β-unsaturated amide or ester, undergoes a retro-Michael reaction to yield o-aminophenol and the Michael acceptor. This reaction was observed only in protic solvents, such as MeOH and aqueous MeOH. In contrast, o-anisidine was not eliminated from its Michael adduct. o-Aminophenol may be a promising masking tool of highly-reactive bioactive α,β-unsaturated carbonyl compounds.
Synthesis of N-benzylacrylamide
Builov,Popova,Shevchuk,Podgornova
, p. 1718 - 1719 (2002)
A procedure was developed for preparing N-benzylacrylamide in quantitative yield in a single stage from acrylonitrile and benzyl alcohol.
