1187927-77-0Relevant articles and documents
Unforeseen Possibilities to Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives
Khomutov, Maxim,Hyv?nen, Mervi T.,Simonian, Alina,Formanovsky, Andrey A.,Mikhura, Irina V.,Chizhov, Alexander O.,Kochetkov, Sergey N.,Alhonen, Leena,Veps?l?inen, Jouko,Kein?nen, Tuomo A.,Khomutov, Alex R.
, p. 11335 - 11347 (2019)
The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present in millimolar concentrations in all eukaryotic cells participating in the regulation of vital cellular functions including proliferation and differentiation. The desig
Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine
Chizhov, A. O.,Hyv?nen, M. T.,Kein?nen, T. A.,Khomutov, A. R.,Khomutov, M. A.,Kochetkov, S. N.,Ryzhov, I. M.,Salikhov, A. I.,Veps?l?inen, J.
, p. 1061 - 1066 (2020/12/30)
Abstract: A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C?methylated spermine (Spm) analogue, 1,12-diamino-3,10-dimethyl-4,9-diazadodecane (3,10-Me2Spm), starting from commercially available enanti
Enantioselective synthesis of (R)- and (S)-3-methylspermidines
Khomutov,Keinanen,Hyvonen,Weisell,Vepsalainen,Alhonen,Kochetkov,Khomutov
, p. 548 - 553 (2015/10/12)
Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized within 11 steps with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1
SUBSTITUTED FUSED[1,2]IMIDAZO[4,5-C] RING COMPOUNDS AND METHODS
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Page/Page column 113, (2008/06/13)
[1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.