1187932-20-2Relevant academic research and scientific papers
Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists
Jin, Jian,Dhanak, Dashyant,Knight, Steven D.,Widdowson, Katherine,Aiyar, Nambi,Naselsky, Diane,Sarau, Henry M.,Foley, James J.,Schmidt, Dulcie B.,Bennett, Carl D.,Wang, Bing,Warren, Gregory L.,Moore, Michael L.,Keenan, Richard M.,Rivero, Ralph A.,Douglas, Stephen A.
, p. 3229 - 3232 (2005)
High throughput screening of the corporate compound collection led to the discovery of a novel series of substituted aminoalkoxybenzyl pyrrolidines as human urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that led to the identification of a truncated sub-series, represented by SB-436811 (1a), are described.
Discovery of novel and long acting muscarinic acetylcholine receptor antagonists
Jin, Jian,Wang, Yonghui,Shi, Dongchuan,Wang, Feng,Davis, Roderick S.,Jin, Qi,Fu, Wei,Foley, James J.,Webb, Edward F.,Dehaas, Chris J.,Berlanga, Manuela,Burman, Miriam,Sarau, Henry M.,Morrow, Dwight M.,Rao, Parvathi,Kallal, Lorena A.,Moore, Michael L.,Rivero, Ralph A.,Palovich, Michael,Salmon, Michael,Belmonte, Kristen E.,Busch-Petersen, Jakob
supporting information; experimental part, p. 4866 - 4869 (2009/08/09)
High throughput screening and subsequent optimization led to the discovery of novel quaternary ammonium salts as highly potent muscarinic acetylcholine receptor antagonists with excellent selectivity. Compounds 8a, 13a, and 13b showed excellent inhibitory
NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
-
Page/Page column 17-18, (2008/06/13)
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
NOVEL M3 MUSCARINIC ACETYCHOLINE RECEPTOR ANTAGONISTS
-
Page/Page column 27, (2008/06/13)
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
Urotensin-II receptor antagonists
-
, (2008/06/13)
The present invention relates to pyrrolidiones, pharmaceutical compostions containing them and their use as antagonist of urotensin II.
Urotensin-II receptor antagonists
-
, (2008/06/13)
The present invention relates to pyrrolyl and pyridyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of urotensin II.
