1187951-63-8

Basic information

• Product Name: C₂₄H₂₁N₃O₃S
• Synonyms: C₂₄H₂₁N₃O₃S
• CAS NO: 1187951-63-8
• Molecular Weight: 431.515
• Mol File: 1187951-63-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₁N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₁N₃O₃S(1187951-63-8)
• EPA Substance Registry System: C₂₄H₂₁N₃O₃S(1187951-63-8)

Safety Data

• Hazardous Substances Data: 1187951-63-8(Hazardous Substances Data)

Upstream product

• 1187951-46-7 C₂₄H₂₁N₃O₅S₂ 
• 5720-07-0 4-methoxyphenylboronic acid 
• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Substituent effect of imino-o-arenesulfonates, a coupling partner in Suzuki-Miyaura reaction for substitution of the pyrazine ring: A study for the synthesis of coelenterazine analogs

Amino(aryl)pyrazines, a key intermediate in the synthesis of coelenterazine and its analogs, can be prepared in excellent yields by utilizing imino-O-tosylates in the SuzukiMiyaura reaction. These imino-O-tosylates serve as a substitute for the corresponding imino-O-triflates, which are sometimes too unstable to be stored during the optimization of the reaction conditions. Aryltrifluoroborates, a coupling partner, worked well when arylboronic acids or arylboronate esters were less reactive. Aryltrifluoroborates also worked well when containing an electron-donating group attached to the aromatic ring. The study of the substituent effect of imino-O-arenesulfonates demonstrated a major difference in the rate of the reactions when changing from electron-donating groups to electron-withdrawing groups at the para position of arenesulfonates. Imino-O-arenesulfonate containing a para-bromo substituent only gave the desired coupling product leaving the para substituent of arenesulfonate untouched.