1187975-72-9

Upstream product

• 868286-32-2 3-amino-N-[(R)-1-(4-fluorophenyl)ethyl]-5-(methanesulfonyl(methyl)amino)benzamide 
• 364368-78-5 C₁₂H₁₂O₄ 

Downstream Products

• 1187975-80-9 4-((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)benzoic acid methyl ester 
• 1187975-76-3 2-benzyl-2-hydroxypentanedioic acid 5-[((S)-1-benzylcarbamoyl-2-methylpropyl)amide] 1-{[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenyl]amide} 
• 1187975-75-2 2-benzyl-2-hydroxypentanedioic acid 1-{[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenyl]amide} 5-[((1S,2R)-2-hydroxyindan-1-yl)amide] 
• 1187975-79-6 4-[((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)methyl]benzoic acid methyl ester 

Relevant academic research and scientific papers

Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic

Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. The most potent inhibitor exhibited a BACE-1 IC50 value of 0.23 μM.