Cas 1187975-80-9,4-((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)benzoic acid methyl ester

1187975-80-9

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Basic information

Product Name: 4-((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)benzoic acid methyl ester
Synonyms: 4-((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)benzoic acid methyl ester
CAS NO:1187975-80-9
Molecular Formula:
Molecular Weight: 817.936
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4-((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)benzoic acid methyl ester(CAS DataBase Reference)
NIST Chemistry Reference: 4-((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)benzoic acid methyl ester(1187975-80-9)
EPA Substance Registry System: 4-((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)benzoic acid methyl ester(1187975-80-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1187975-80-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1187975-80-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,9,7 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1187975-80:
(9*1)+(8*1)+(7*8)+(6*7)+(5*9)+(4*7)+(3*5)+(2*8)+(1*0)=219
219 % 10 = 9
So 1187975-80-9 is a valid CAS Registry Number.

1187975-80-9Upstream product

1187975-80-9Downstream Products

1187975-82-1 4-((S)-2-{4-[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenylcarbamoyl]-4-hydroxy-5-phenylpentanoylamino}-3-methylbutyrylamino)benzoic acid

1187975-80-9Relevant academic research and scientific papers

Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic

Wangsell, Fredrik,Russo, Francesco,Saevmarker, Jonas,Rosenquist, Asa,Samuelsson, Bertil,Larhed, Mats

supporting information; experimental part, p. 4711 - 4714 (2010/04/28)

Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. The most potent inhibitor exhibited a BACE-1 IC50 value of 0.23 μM.

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