118799-81-8

Basic information

• Product Name: methyl (E)-3-<(2R*,3R*)-2,3-dihydro-7-methoxy-3-methoxycarbonyl-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl>propenoate
• Synonyms: methyl (E)-3-<(2R*,3R*)-2,3-dihydro-7-methoxy-3-methoxycarbonyl-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl>propenoate
• CAS NO: 118799-81-8
• Molecular Weight: 458.465
• Mol File: 118799-81-8.mol

Chemical Properties

• CAS DataBase Reference: methyl (E)-3-<(2R*,3R*)-2,3-dihydro-7-methoxy-3-methoxycarbonyl-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl>propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-3-<(2R*,3R*)-2,3-dihydro-7-methoxy-3-methoxycarbonyl-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl>propenoate(118799-81-8)
• EPA Substance Registry System: methyl (E)-3-<(2R*,3R*)-2,3-dihydro-7-methoxy-3-methoxycarbonyl-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl>propenoate(118799-81-8)

Safety Data

• Hazardous Substances Data: 118799-81-8(Hazardous Substances Data)

Upstream product

• 118799-80-7 (E)-methyl 3-<(2RS,3SR)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methoxycarbonyl-1-benzofuran-5-yl>-1-propenoate 
• 107-30-2 chloromethyl methyl ether 
• 5533-00-6 3-methoxy-4-methoxymethoxy-benzaldehyde 
• 121-33-5 vanillin 
• 2309-07-1 Methyl ferulate 

Downstream Products

• 118799-83-0 (E)-3-<(2R*,3S*)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl>-2-propen-1-ol 
• 187655-56-7 (±)-trans-grossamide 
• 118916-57-7 (E)-3-[2-(4-Hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydrobenzo[b]furan-5-yl]-2-propenal 
• 118799-85-2 (E)-3-[(2R*,3S*)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl]-2-propenal 
• 118799-86-3 methyl (E)-3-<(2R*,3S*)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-1-benzofuran-5-yl>propenoate 
• 118799-84-1 methyl (E)-3-<(2R*,3S*)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl>propenoate 

Relevant articles and documents

Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities

Stilbenes and benzofuran neolignans are important groups of plant phenolics therefore they play a significant role in plants and human health. The objective of this study was to investigate the structure-activity relationships of naturally occurring stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors. A series of these compounds were prepared and assessed for their inhibition on acetylcholinesterase activity. δ-Viniferin, pterostilbene trans-dehydrodimer, pallidol, grossamide, and boehmenan exerted acetylcholinesterase inhibitory potential. The several oligomeric compounds protected against cell damage resulting from t-BHP exposure and inhibited lipopolysaccharide/interferon-gamma (LPS/IFNγ)-induced NO production in vitro. Our findings highlight the great potential of pterostilbene trans-dehydrodimer, pallidol, and boehmenan as multifunctional nutraceuticals for management of neurodegenerative diseases.

General approach to neolignan-core of the boehmenan natural product family

Abstract: A novel approach to the neolignan-core skeletons of boehmenan natural products and to dehydrodiconiferyl alcohol glucosides based on the Fe(III)-promoted oxidative coupling has been achieved. Obtained common intermediates were further selectively modified to yield the basic molecular core possessing three orthogonally protected alkoxy functionalities available for further selective modifications. Graphical abstract: [Figure not available: see fulltext.].

Total Synthesis of Two Naturally Occurring Neolignans of Potential Biological Activity

The first synthesis of the racemates of two naturally occurring neolignans, 1 and 2, was accomplished starting from methyl ferulate.