1188-07-4

Basic information

• Product Name: (2S)-2-amino-6-methylamino-hexanoic acid
• Synonyms: (2S)-2-amino-6-methylamino-hexanoic acid;N(6)-Methyllysine;epsilon-N-methyllysine;N6-Methyl-L-lysine;L-Lysine, N6-Methyl-
• CAS NO: 1188-07-4
• Molecular Formula: C₇H₁₆N₂O₂
• Molecular Weight: 160.21
• Mol File: 1188-07-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 295.7°Cat760mmHg
• Flash Point: 132.7°C
• Appearance: /
• Density: 1.056g/cm³
• Vapor Pressure: 0.000363mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: (2S)-2-amino-6-methylamino-hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-amino-6-methylamino-hexanoic acid(1188-07-4)
• EPA Substance Registry System: (2S)-2-amino-6-methylamino-hexanoic acid(1188-07-4)

Safety Data

• Hazardous Substances Data: 1188-07-4(Hazardous Substances Data)

Usage

Definition

ChEBI: An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N6 is substituted by a methyl group.

InChI:InChI=1/C7H16N2O2/c1-9-5-3-2-4-6(8)7(10)11/h6,9H,2-5,8H2,1H3,(H,10,11)/t6-/m0/s1

Upstream product

• 50-00-0 formaldehyd 
• 56-87-1 L-lysine 
• 51021-86-4 α-N-Benzyloxycarbonyl-ε-N-benzyl-L-lysin 
• 1432516-15-8 C₂₄H₃₂N₄O₄ 

Relevant articles and documents

Binding Methylarginines and Methyllysines as Free Amino Acids: A Comparative Study of Multiple Host Classes**

Methylated free amino acids are an important class of targets for host-guest chemistry that have recognition properties distinct from those of methylated peptides and proteins. We present comparative binding studies for three different host classes that are each studied with multiple methylated arginines and lysines to determine fundamental structure-function relationships. The hosts studied are all anionic and include three calixarenes, two acyclic cucurbiturils, and two other cleft-like hosts, a clip and a tweezer. We determined the binding association constants for a panel of methylated amino acids using indicator displacement assays. The acyclic cucurbiturils display stronger binding to the methylated amino acids, and some unique patterns of selectivity. The two other cleft-like hosts follow two different trends, shallow host (clip) following similar trends to the calixarenes, and the other more closed host (tweezer) binding certain less-methylated amino acids stronger than their methylated counterparts. Molecular modelling sheds some light on the different preferences of the various hosts. The results identify hosts with new selectivities and with affinities in a range that could be useful for biomedical applications. The overall selectivity patterns are explained by a common framework that considers the geometry, depth of binding pockets, and functional group participation across all host classes.

Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?

A small library of peptide amides was designed to profile the cathepsin L active site. Within the cathepsin family of cysteine proteases, the first round of selection was on cathepsin L and cathepsin B, and then selected hits were further evaluated for binding to cathepsin K and cathepsin S. Five highly selective sequences with submicromolar affinities towards cathepsin L were identified. An acyloxymethyl ketone warhead was then attached to these sequences. Although these original irreversible inhibitors inactivate cathepsin L, it appears that the nature of the warhead drastically impact the selectivity profile of the resulting covalent inhibitors.

Spontaneous N epsilon-methylation of L-lysine by formaldehyde.

It has been found that the conversion of L-lysine (1) into its corresponding N epsilon-methylated derivatives, mainly N epsilon-mono-methyl-L-lysine (5; MML), but also N epsilon, N epsilon-dimethyl-L-lysine (DML) and N epsilon, N epsilon, N epsilon-trimethyl-L-lisine (TML) takes place by treatment with formaldehyde in spontaneous reaction. The identification of N epsilon-methylated lysines was carried out by different chromatographic and spectroscopic methods. This spontaneous N epsilon-methylation of L-lysine by formaldehyde may also play an important role in living organisms.