1188024-51-2Relevant academic research and scientific papers
A metal-free and recyclable synthesis of benzothiazoles using thiourea as a sulfur surrogate
Yin, Yan,Zhou, Hong,Liu, Xichen,Chen, Haiying,Wu, Fanhong,Zhang, Heng,Tao, Ruiheng,Cheng, Fengkai,Feng, Yangbo
supporting information, p. 1709 - 1712 (2015/03/14)
Using odorless thiourea as the S source, benzothiazoles and asymmetric disulfides could be obtained from thioformanilides through the tandem cyclization/nucleophilic addition/hydrolysis/nucleophilic substitution reaction. Furthermore, the obtained asymmetric disulfides could readily transfer to benzothiazoles after nitro-reduction and amide formation reaction. This metal-free and recyclable synthetic methodology offered a time-efficient, less expensive, and environmentally friendly alternative to multifunctional benzothiazoles.
