118832-53-4Relevant articles and documents
Formal, Stereoselective Synthesis of Hydroxyethylene Dipeptide Isosteres Utilizing Pseudoephedrine Amides
Dragovich, Peter S.,Prins, Thomas J.,Zhou, Ru
, p. 7872 - 7876 (2007/10/03)
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AN EFFICIENT SYNTHESIS OF THE γ-LACTONE CORRESPONDING TO A HYDROXYETHYLENE DIPEPTIDE ISOSTERE USING STEREOSELECTIVE BROMOLACTONISATION OF A CHIRAL ACYLOXAZOLIDINONE
Bradbury, Robert H.,Revill, John M.,Rivett, Janet E.,Waterson, David
, p. 3845 - 3848 (2007/10/02)
An efficient synthetic route is described to the γ-lactone 11 corresponding to the dipeptide isostere (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanoic acid, in which stereochemical control is achieved by participation of chiral acyloxazolidinone 6 in a stereoselective bromolactonisation reaction.