118832-53-4

Upstream product

• 118040-79-2 1-cyclohexylbut-3-en-2-ol 
• 196706-22-6 (E)-6-cyclohexyl-2-(1-methylethyl)-4-hexenoic acid 
• 118917-71-8 (4E,2S)-6-cyclohexyl-2-(1-methylethyl)-4-hexenoic acid 
• 96930-24-4 (4S)-N-(3-methylbutanoyl)-4-(1-methylethyl)-2-oxazolidinone 
• 128901-47-3 (E)-4-cyclohexyl-1-iodo-2-butene 
• 4442-79-9 cyclohexylethan-1-ol 
• 118832-47-6 (E)-6-Cyclohexyl-2-isopropyl-hex-4-enoic acid ethyl ester 
• 118917-67-2 (E)-(S)-6-Cyclohexyl-2-isopropyl-hex-4-enoyl chloride 
• 759-36-4 diethyl isopropylmalonate 
• 192060-34-7 N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-N-dimethylbutyramide 
• 108-12-3 isopentanoyl chloride 
• 5664-21-1 cyclohexylacetaldehyde 
• 118832-49-8 (E)-4-bromo-1-cyclohexyl-2-butene 
• 196706-16-8 (E)-(S)-6-Cyclohexyl-2-isopropyl-hex-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 

Relevant academic research and scientific papers

A Versatile and Stereocontrolled Synthesis of Hydroxyethylene Dipeptide Isosteres

An asymmetric synthesis of the hydroxyethylene dipeptide isostere unit 1 is described.The synthesis provides excellent stereocontrol over all three chiral centers and is amenable to variation of substituents R1 and R2.Key intermediat

AN EFFICIENT SYNTHESIS OF THE γ-LACTONE CORRESPONDING TO A HYDROXYETHYLENE DIPEPTIDE ISOSTERE USING STEREOSELECTIVE BROMOLACTONISATION OF A CHIRAL ACYLOXAZOLIDINONE

An efficient synthetic route is described to the γ-lactone 11 corresponding to the dipeptide isostere (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanoic acid, in which stereochemical control is achieved by participation of chiral acyloxazolidinone 6 in a stereoselective bromolactonisation reaction.