128901-47-3

Upstream product

• 5664-21-1 cyclohexylacetaldehyde 
• 128901-46-2 (E)-1-chloro-4-cyclohexyl-2-butene 
• 4442-79-9 cyclohexylethan-1-ol 

Downstream Products

• 128948-63-0 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(R)-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (2-dimethylamino-ethyl)-amide 
• 128901-37-1 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (2-dimethylamino-ethyl)-amide 
• 128901-39-3 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (2-morpholin-4-yl-ethyl)-amide 
• 128901-40-6 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (2-piperazin-1-yl-ethyl)-amide 
• 128901-41-7 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (pyridin-2-ylmethyl)-amide 
• 128901-44-0 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (2-dimethylamino-ethyl)-methyl-amide 
• 128901-45-1 N-[(1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-(morpholine-4-carbonyl)-hexyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide 
• 128901-42-8 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (4-hydroxy-butyl)-amide 
• 128901-43-9 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide 
• 128901-38-2 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (2-amino-ethyl)-amide 
• 128901-48-4 N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide 
• 118832-53-4 (3S,5R)-5-((S)-1-Bromo-2-cyclohexyl-ethyl)-3-isopropyl-dihydro-furan-2-one 
• 125816-10-6 <3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone 
• 128948-72-1 (4S)-4-benzyl-3-<(2S,4E)-6-cyclohexyl-2-isopropylhex-4-enoyl>oxazolidin-2-one 

Relevant academic research and scientific papers

1,2,4-Triazolopyrazine Derivatives with Human Renin Inhibitory Activity. 2. Synthesis, Biological Properties and Molecular Modeling of Hydroxyethylene Isostere Derivatives

A series of inhibitors of human renin have been synthesized, derived from combination of a 2-(8-propyl-6-pyridin-3-yl-1,2,4-triazolopyrazin-3-yl)-3-pyridin-3-ylpropionic acid moiety 6c with the hydroxyethylene isostere of the scissile amide bond (2

AN EFFICIENT SYNTHESIS OF THE γ-LACTONE CORRESPONDING TO A HYDROXYETHYLENE DIPEPTIDE ISOSTERE USING STEREOSELECTIVE BROMOLACTONISATION OF A CHIRAL ACYLOXAZOLIDINONE

An efficient synthetic route is described to the γ-lactone 11 corresponding to the dipeptide isostere (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanoic acid, in which stereochemical control is achieved by participation of chiral acyloxazolidinone 6 in a stereoselective bromolactonisation reaction.