1188401-70-8

Basic information

• Product Name: C₁₉H₁₅NO₃
• CAS NO: 1188401-70-8
• Molecular Weight: 305.333
• Mol File: 1188401-70-8.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₅NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₅NO₃(1188401-70-8)
• EPA Substance Registry System: C₁₉H₁₅NO₃(1188401-70-8)

Safety Data

• Hazardous Substances Data: 1188401-70-8(Hazardous Substances Data)

Upstream product

• 2107-69-9 5,6-dimethoxy-1-indanone 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 1204607-47-5 C₁₉H₁₄BrNO₃ 
• 1351837-16-5 4-[2-(4-aminobenzoyl)-6,7-dimethoxy-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-3-yl]benzonitrile 
• 1351837-40-5 4-[6,7-dimethoxy-2-(3-methoxybenzoyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-3-yl]benzonitrile 
• 1351837-28-9 4-[2-(3,4-dimethoxybenzoyl)-6,7-dimethoxy-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-3-yl]benzonitrile 

Relevant articles and documents

Discovery of novel methanone derivatives acting as antimycobacterial agents

A series of pyrazoline derivatives were synthesized and in vitro activity against Mycobacterium tuberculosis H37Rv was carried out. Among the synthesized compounds, compounds (4d) and (4f) 4-aminophenyl-3-(3,4-dimethoxyphenyl)-6,7- dimethoxy-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone and 4-aminophenyl-6,7-dimethoxy-3-phenyl-2,3,3a,4-tetrahydroindeno[1,2-c] pyrazol-2-ylmethanone were found to be the most active agent against M. tuberculosis H37Rv with a minimum inhibitory concentration of 10μg/mL.

Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues

In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenylmethanone analogues were synthesized and were tested for their potential for treating AD disease. All the newly synthesized compounds were showing moderate to high AChE inhibitory activities, with compound 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone (5f) produced significant activities with 2.7 ± 0.01 μmol/L.

Synthesis and antimycobacterial evaluation of novel 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-5,4-substituted phenyl methanone analogues

In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenylmethanone analogues were synthesized and were evaluated for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and INH resistant M. tuberculosis. All the newly synthesized compounds were showing moderate to high inhibitory activities. The compound 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-4-fluorophenylmethanone (5g) was found to be the most promising compounds active against M. tuberculosis H37Rv and isoniazid (INH) resistant M. tuberculosis with Minimum inhibitory concentration 0.10 and 0.10 μM.