1351837-40-5Relevant articles and documents
Discovery of novel methanone derivatives acting as antimycobacterial agents
Ali, Mohamed Ashraf,Bastian, Sylvaine,Ismail, Rusli,Choon, Tan Soo,Ali, Sadath,Aubry, Alexandra,Pandian, Suresh,Saraswat, Pankaj,Singh, Abhimanyu,Gaur, Ramakant
, p. 890 - 894 (2012/03/11)
A series of pyrazoline derivatives were synthesized and in vitro activity against Mycobacterium tuberculosis H37Rv was carried out. Among the synthesized compounds, compounds (4d) and (4f) 4-aminophenyl-3-(3,4-dimethoxyphenyl)-6,7- dimethoxy-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone and 4-aminophenyl-6,7-dimethoxy-3-phenyl-2,3,3a,4-tetrahydroindeno[1,2-c] pyrazol-2-ylmethanone were found to be the most active agent against M. tuberculosis H37Rv with a minimum inhibitory concentration of 10μg/mL.