1188522-81-7

Basic information

• Product Name: 3',5'-Di-O-acetyl-5-broMo-2'-O-Methyluridine
• Synonyms: 3',5'-Di-O-acetyl-5-broMo-2'-O-Methyluridine;5-Bromo-2'-O-methyluridine 3',5'-diacetate;SRIIZANGRRSQIV-PRULPYPASA-N
• CAS NO: 1188522-81-7
• Molecular Formula: C14H17BrN2O8
• Molecular Weight: 421.19738
• Mol File: 1188522-81-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3',5'-Di-O-acetyl-5-broMo-2'-O-Methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-Di-O-acetyl-5-broMo-2'-O-Methyluridine(1188522-81-7)
• EPA Substance Registry System: 3',5'-Di-O-acetyl-5-broMo-2'-O-Methyluridine(1188522-81-7)

Safety Data

• Hazardous Substances Data: 1188522-81-7(Hazardous Substances Data)

Upstream product

• 61671-79-2 3',5'-di-O-acetyl-2'-O-methyluridine 
• 2140-76-3 2'-O-methyluridine 
• 108-24-7 acetic anhydride 
• 34218-83-2 5-bromo-2'-O-methyluridine 

Downstream Products

• 1393486-73-1 C₅₂H₆₄N₆O₁₀P 
• 1393486-78-6 C₄₃H₄₅N₄O₉ 
• 1188522-86-2 3-(5'-O-dimethoxytrityl-2'-O-methyl-β-D-ribofuranosyl)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 
• 1174063-88-7 3-(5'-O-dimethoxytrityl-2'-O-methyl-β-D-ribofuranosyl)-1,3-diaza-2-oxophenoxazine 
• 1188522-83-9 5-bromo-3',5'-diacetyl 2'-O-metnyl-N₄-(2-hydroxyphenyl)cytidine 

Relevant articles and documents

Synthesis and characterization of RNA containing a rigid and nonperturbing cytidine-derived spin label

The nitroxide-containing nucleoside Cm is reported as the first rigid spin label for paramagnetic modification of RNA by solid-phase synthesis. The spin label is well accommodated in several RNA secondary structures as judged by its minor effect on the thermodynamic stability of hairpin and duplex RNA. Electron paramagnetic resonance (EPR) spectroscopic characterization of mono-, bi-, and trimolecular RNA structures shows that Cm will be applicable for advanced EPR studies to elucidate structural and dynamic aspects of folded RNA.

NON-NATURAL RIBONUCLEOTIDES, AND METHODS OF USE THEREOF

One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such modified nucleosides. Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) co