118887-71-1

Basic information

• Product Name: 1-Propanone, 2-azido-2-methyl-1-phenyl-
• CAS NO: 118887-71-1
• Molecular Formula: C10H11N3O
• Molecular Weight: 189.217
• Mol File: 118887-71-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-azido-2-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-azido-2-methyl-1-phenyl-(118887-71-1)
• EPA Substance Registry System: 1-Propanone, 2-azido-2-methyl-1-phenyl-(118887-71-1)

Safety Data

• Hazardous Substances Data: 118887-71-1(Hazardous Substances Data)

Usage

Appearance

Pale yellow liquid with a faint odor

Usage

Intermediate in the synthesis of other organic compounds, production of pharmaceuticals, agrochemicals, and other fine chemicals

Hazards

Potentially hazardous if not handled properly, should be stored and used in accordance with safety guidelines

Upstream product

• 611-70-1 phenyl isopropyl ketone 
• 38744-73-9 2,2-dimethyl-3-phenyl-3-oxopropanoic acid 
• 104015-38-5 tert-butyl 2-benzoylpropionate 
• 26735-95-5 2-methyl-3-hydroxy-3-phenylpropionic acid t-butyl ester 
• 53935-56-1 tert-butyl 2,2-dimethyl-3-oxo-3-phenylpropanoate 
• 100-52-7 benzaldehyde 
• 10409-54-8 2-bromo-2-methyl-1-phenyl-propan-1-one 

Downstream Products

• 78007-50-8 N-(prop-1-en-2-yl)benzamide 
• 874813-10-2 2-amino-2-methyl-1-phenyl-propan-1-one p-toluenesulfonate 
• 115046-25-8 (2-Azido-1-fluoro-2-methyl-propyl)-benzene 

Relevant articles and documents

Oxidative azidations of phenols and ketones using iodine azide after release from an ion exchange resin

The oxidative oligoazidation of phenols and ketones using iodine azide (IN3) provided by its release from an ion exchange resin is reported. Preliminary mechanistic studies indicate a previously unknown reactivity of iodine azide toward phenols and ketones.

Iron-Catalyzed Acyl Migration of Tertiary α-Azidyl Ketones: Synthetic Approach toward Enamides and Isoquinolones

This paper reports that tertiary α-azidyl phenyl ketones can be transformed into enamides by treatment with FeBr2 at elevated temperature in DMF. The reaction proceeds via 1,2-benzoyl migration from α-carbon to the nitrogen atom, accompanied by expulsion of a nitrogen molecule. This protocol is suitable for the synthesis of N-(cyclopent-1-en-1-yl)benzamides, N-(cyclohex-1-en-1-yl)benzamides, and N-benzoyl-α-methyl enamines and provides a convenient approach toward isoquinolones.

11-Beta HSD1 inhibitors

This invention relates to inhibiting 11-beta HSD1.