1188906-89-9

Basic information

• Product Name: methyl 5-(2-chloroethoxy)-4-methoxy-2-nitrobenzoate
• Synonyms: methyl 5-(2-chloroethoxy)-4-methoxy-2-nitrobenzoate
• CAS NO: 1188906-89-9
• Molecular Weight: 289.672
• Mol File: 1188906-89-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 5-(2-chloroethoxy)-4-methoxy-2-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-(2-chloroethoxy)-4-methoxy-2-nitrobenzoate(1188906-89-9)
• EPA Substance Registry System: methyl 5-(2-chloroethoxy)-4-methoxy-2-nitrobenzoate(1188906-89-9)

Safety Data

• Hazardous Substances Data: 1188906-89-9(Hazardous Substances Data)

Upstream product

• 215659-03-3 methyl 5-hydroxy-4-methoxy-2-nitrobenzoate 
• 107-04-0 1-Bromo-2-chloroethane 
• 31839-20-0 5-hydroxy-4-methoxy-2-nitrobenzoic acid 
• 1176169-43-9 C₁₀H₁₁ClO₄ 
• 165121-44-8 3-(2-chloroethoxy)-4-methoxybenzaldehyde 
• 621-59-0 isovanillin 
• 6702-50-7 3-hydroxy-4-methoxybenzoate 
• 895244-45-8 methyl 3-(2-chloroethoxy)-4-methoxybenzoate 

Downstream Products

• 1188906-90-2 methyl 2-amino-5-(2-chloroethoxy)-4-methoxybenzoate 
• 1188906-96-8 1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-methoxy-6-(2-morpholinoethoxy)quinazolin-4-yloxy)phenyl)urea 
• 1188906-92-4 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-(2-chloroethoxy)-7-methoxyquinazolin-4-yloxy)phenyl)urea 
• 1456070-13-5 C₂₁H₂₂ClFN₄O₃ 
• 1456070-12-4 C₂₀H₂₀ClFN₄O₃ 
• 808793-73-9 4-(3-chloro-4-fluorophenylamino)-7-methoxy-6-(2-chloroethoxy)quinazoline 
• 1456070-11-3 C₂₂H₂₂ClFN₄O₄S 
• 1456070-10-2 C₂₂H₂₂ClFN₄O₂S 
• 1456070-09-9 C₂₂H₂₂ClFN₄O₃ 
• 1445861-29-9 4-(3'-chloro-4'-fluorophenylamino)-6-[2-(2-oxa-6-azaspiro[3.3]heptane-6-yl)oxethyl]-7-methoxyquinazoline 

Relevant articles and documents

PDIA4 INHIBITORS AND USE THEREOF FOR INHIBITING ?-CELL PATHOGENESIS AND TREATING DIABETES

Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.

4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors

Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy) phenyl)urea hydrochloride) exhibits good pharmacokinetic properties in rat and mouse and is efficacious in a mouse tumor xenograft model following oral dosing.