118893-61-1Relevant articles and documents
Synthetic efforts toward the macrolactone core of leucascandrolide A
Ferrie, Laurent,Boulard, Lucie,Pradaux, Fabienne,Bouzbouz, Samir,Reymond, Sebastien,Capdevielle, Patrice,Cossy, Janine
, p. 1864 - 1880 (2008/09/18)
(Chemical Equation Presented) A chemoselective synthesis of 1, the macrocyclic core of leucascandrolide A, has been achieved by utilizing highly enantioselective allylmetalations, an enantioselective Noyori reduction of a propargylic ketone, and olefin metatheses as the key steps.
Synthesis of leucascandrolide A via a spontaneous macrolactolization
Wang, Ying,Janjic, Jelena,Kozmin, Sergey A.
, p. 13670 - 13671 (2007/10/03)
We have developed a concise, convergent, and stereocontrolled synthesis of (±)-leucascandrolide A (18 steps from commercially available precursors), featuring a complete relay of the initial stereochemical information via a series of diastereoselective transformations. Spontaneous macrolactolization discovered during this synthetic exercise has provided unprecedented access to this macrolide and demonstrated the possibility of accessing even large-ring systems in a highly controlled and efficient manner. Copyright
