118917-64-9

Usage

Chemical structure

A chemical compound synthesized by reacting benzyloxymethyl chloride with tri(ethylene glycol).

Usage

Commonly used as a reagent in organic synthesis and as a protective agent for hydroxyl groups in organic compounds.

Physical appearance

A colorless to pale yellow liquid with a mild odor.

Solubility

Soluble in water, alcohol, and ether.

Stability

Considered to be a relatively stable compound under normal conditions.

Safety precautions

Should be handled and stored with care due to its potential as a skin and eye irritant.

Reactivity

Has the potential to react with strong oxidizing agents and acids, so appropriate precautions should be taken during its use and storage.

Upstream product

• 100-39-0 benzyl bromide 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 16495-03-7 (S)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 80525-59-3 4-[(benzyloxy)methyl]-3,6-dioxaoctane-1,8-dicarboxylic acid 
• 79-11-8 chloroacetic acid 

Downstream Products

• 137743-85-2 12-Benzyloxymethyl-28-methoxy-2,5,8,11,14,17,20,23-octaoxa-bicyclo[22.3.1]octacosa-1⁽²⁷⁾,24⁽²⁸⁾,25-triene 
• 107094-28-0 2-<(benzyloxy)methyl>-19-crown-6 

Relevant academic research and scientific papers

Synthesis of lipophilic lariat ethers with pendant N-(X)sulfonyl carboxamide groups

Synthetic routes to sixteen lipophilic lariat ether N-(X)sulfonyl carboxamides with X = trifluoromethyl, methyl, phenyl, and p-nitrophenyl are described. For this new family of proton-ionizable lariat ethers in which the acidity can be 'tuned' by X group variation, the ring size is systematically varied from 12-crown-4 to 14-crown-4 to 15-crown-5 to 18-crown-6.

MACROCYCLIC CHELATORS AND METHODS OF USE THEREOF

Macrocyclic chelators (I) for chelation of alpha-emitting radiometal ions, such as actinium-225 are provided. Also provided are radiometal complexes containing an alpha-emitting radiometal ion bound to the macrocyclic chelator via coordinate bonding, and radioimmunoconjugates containing the radiometal complexes covalently linked to a targeting ligand, such as an antibody or antigen binding fragment thereof. The radioimmunoconjugates can be produced by click chemistry reactions. Methods of using the radiocomplexes and radioimmunoconjugates for selectively targeting neoplastic cells for radiotherapy and for treating neoplastic diseases and disorders are also described.

Synthesis of New Proton-Ionizable Dibenzocrown Ethers

A series of structurally related dibenzo-15-crown-5, dibenzo-18-crown-6, and dibenzo-21-crown-7 compounds with oxymethylacetoxy side arms is synthesized by reaction of the corresponding crown ether alcohols with potassium hydride and bromoacetic acid. Mul

Phase-Transfer-Catalyzed Synthesis of Oligoethylene Glycols and Derivatives

An efficient, two-step synthetic method for the addition of ethyleneoxy units to diols is reported.Reaction of HOROH with Cl(CH2CH2O)nTHP and 50percent aqueous NaOH in the presence of a phase-transfer catalyst gives THP(OCH2CH2)nORO(CH2CH2O)nTHP from which the protecting groups are readily removed to provide H(OCH2CH2)nORO(CH2CH2O)n in good-to-excellent yields.The influence of reactant diol structure upon yield has been determined.

NEW LIPOPHILIC IONIZABLE CROWN ETHERS

Two new ionizable crown ethers which bear lipophilic groups are synthesized and found to exhibit selectivity for complexation of K(1+) in competitive solvent extractions of alkali metal cations.