1189186-53-5Relevant academic research and scientific papers
Reagent-controlled enantioselectivity switch for the asymmetric fluorination of β-ketocarbonyls by chiral primary amine catalysis
You, Yang'en,Zhang, Long,Luo, Sanzhong
, p. 621 - 626 (2016)
A reagent-controlled enantioselectivity switch was uncovered in the asymmetric α-fluorination of β-ketocarbonyls by a chiral primary amine catalyst. By a simple swap of fluorination reagents, both enantiomers of the quaternary fluorination adducts could be obtained with good yields and high enantioselectivity. Mechanistic studies disclosed dual H-bonding and electrostatic stereocontrolling modes for the catalysis.
Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill
Wang, Yifeng,Wang, Haojiang,Jiang, Yidong,Zhang, Cheng,Shao, Juanjuan,Xu, Danqian
supporting information, p. 1674 - 1677 (2017/06/05)
A fast and highly enantioselective fluorination of β-keto esters catalyzed by diphenylamine linked bis(oxazoline)-Cu(OTf)2 complexes under solvent-free conditions has been developed using a planetary ball mill. High yields, high enantioselectivities and shorter reaction times were achieved with low catalyst loading.
Enantioselective halogenation of β-oxo esters catalyzed by a chiral sulfoximine-copper complex
Frings, Marcus,Bolm, Carsten
supporting information; experimental part, p. 4085 - 4090 (2009/12/26)
A C1-symmetric amino sulfoximine has been used as a chiral ligand in copper-catalyzed asymmetric halogenation reactions of β-oxo esters. Both the catalyst itself and the reaction conditions were optimized, and 26 fluorinated, chlorinated, and b
