1189339-35-2

Upstream product

• 1189339-34-1 [7-(4-acetyl-phenoxy)-naphthalen-2-yloxy]-acetic acid ethyl ester 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 582-17-2 2,7-Dihydroxynaphthalene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1189339-33-0 1-[4-(7-hydroxy-naphthalen-2-yloxy)-phenyl]-ethanone 

Downstream Products

• 1189339-36-3 3-{4-[7-(2-hydroxy-ethoxy)-naphthalen-2-yloxy]-phenyl}-but-2-en-1-ol 

Relevant academic research and scientific papers

Synthesis of novel 1,2,4-trioxanes and antimalarial evaluation against multidrug-resistant Plasmodium yoelii nigeriensis

Malaria epidemics represent one of the life-threatening diseases to low-income lying countries which subsequently affect the economic and social condition of mankind. In continuation in the development of a novel series of 1,2,4-trioxanes 13a1-c1, 13a2-c2, and 13a3-c3 have been prepared and further converted into their hemisuccinate derivatives 14a1-c1, 14a2-c2, and 14a3-c3 respectively. All these new compounds were evaluated for their antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in mice by both oral and intramuscular (im) routes. Hydroxy-functionalized trioxane 13a1 showed 80% protection and its hemisuccinate derivative 14a1 showed 100% protection at a dose of 48 mg/kg × 4 days by both routes, which is twice active than artemisinin by oral route.

NOVEL HYDROXY FUNCTIONALIZED 1, 2, 4-TRIOXANES AS ANTIMALARIAL AGENTS AND A PROCESS FOR THE PREPARATION THEREOF

The present invention relates to novel hydroxy functionalized 1, 2, 4-trioxanes of general formula (7) useful as antimalarial agents. This invention also relates to a process for the preparation of novel hydroxy functionalized 1, 2, 4- trioxanes and their